Latest Articles
CommentaryEvolutionary Divergence in DNA Damage Responses among FungiCell cycle checkpoints and DNA repair pathways contribute to maintaining genome integrity and are thought to be evolutionarily ancient and broadly conserved. For example, in the yeast Saccharomyces cerevisiae and humans, DNA damage induces activation of a checkpoint effector kinase, Rad53p (human homolog Chk2), to promote cell cycle arrest and transcription of DNA...
Research ArticleThe ChiS-Family DNA-Binding Domain Contains a Cryptic Helix-Turn-Helix VariantRegulating gene expression is essential in all domains of life. This process is commonly facilitated by the activity of DNA-binding transcription factors.
Research ArticleTrade-off between Plasticity and Velocity in Mycelial GrowthTip-growing fungal cells maintain cell polarity at the apical regions and elongate by de novo synthesis of the cell wall. Cell polarity and tip growth rate affect mycelial morphology.
ObservationEnvironmental Isolation of Candida auris from the Coastal Wetlands of Andaman Islands, IndiaCandida auris is a recently emerged multidrug-resistant fungal pathogen capable of causing severe infections in hospitalized patients. Despite its recognition as a human pathogen a decade ago, so far the natural ecological niche(s) of C. auris remains enigmatic.
ObservationCritical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and ReplicationSARS-CoV-2 (the causative agent of COVID-19) is a major public health threat and one of two related coronaviruses that have caused epidemics in modern history. A method of screening potential infectible hosts for preemergent and future emergent coronaviruses would aid in mounting rapid response and intervention strategies during future emergence events.
Research ArticleExtent of Cytomegalovirus Replication in the Human Host Depends on Variations of the HLA-E/UL40 AxisInfection with human cytomegalovirus (HCMV) is associated with substantial morbidity in immunosuppressed patients and after congenital infections. Therefore, development of a vaccine against HCMV is a main public health priority.
Research ArticleQuorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial CompoundBacteria interact and compete with a large community of organisms in their natural environment. Streptococcus mutans is one such organism, and it is an important member of the oral microbiota. We found that S. mutans uses a quorum-sensing system to regulate production of a novel posttranslationally...
CommentaryEnvironmental Candida auris and the Global Warming Emergence HypothesisGlobal warming was proposed to be a contributing cause for the nearly simultaneous emergence of different clades of Candida auris as a nosocomial pathogen in different continents. The global warming emergence hypothesis posits that C. auris existed in the environment prior to its clinical...
Research ArticleThe Predicted Mannosyltransferase GT69-2 Antagonizes RFW-1 To Regulate Cell Fusion in Neurospora crassaCell wall remodeling is a dynamic process that balances cell wall integrity versus cell wall dissolution. In filamentous fungi, cell wall dissolution is required for somatic cell fusion and conidial separation during asexual sporulation.
Research ArticleSynthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal InfectionNeisseria gonorrhoeae has become resistant to most antibiotics in clinical use. Currently, there is no safe and effective vaccine against gonorrhea.