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zinc

  • Open Access
    A Trap-Door Mechanism for Zinc Acquisition by <em>Streptococcus pneumoniae</em> AdcA
    Research Article | Host-Microbe Biology
    A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

    Zinc is an essential nutrient for the virulence of bacterial pathogens such as Streptococcus pneumoniae. Many Gram-positive bacteria use a two-domain lipoprotein for zinc acquisition, but how this class of metal-recruiting proteins acquire zinc and interact with the uptake machinery has remained poorly defined.

    Zhenyao Luo, Jacqueline R. Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L. Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G. Pederick, James C. Paton, Thorben Cordes, Jeffrey R. Harmer, Bostjan Kobe, Christopher A. McDevitt
  • Open Access
    Identification of Zinc-Dependent Mechanisms Used by Group B <em>Streptococcus</em> To Overcome Calprotectin-Mediated Stress
    Research Article | Host-Microbe Biology
    Identification of Zinc-Dependent Mechanisms Used by Group B Streptococcus To Overcome Calprotectin-Mediated Stress

    Group B Streptococcus (GBS) asymptomatically colonizes the female reproductive tract but is a common causative agent of meningitis. GBS meningitis is characterized by extensive infiltration of neutrophils carrying high concentrations of calprotectin, a metal chelator. To persist within inflammatory sites and cause invasive disease, GBS must circumvent host starvation attempts. Here, we identified global requirements for GBS...

    Lindsey R. Burcham, Yoann Le Breton, Jana N. Radin, Brady L. Spencer, Liwen Deng, Aurélia Hiron, Monica R. Ransom, Jéssica da C. Mendonça, Ashton T. Belew, Najib M. El-Sayed, Kevin S. McIver, Thomas E. Kehl-Fie, Kelly S. Doran
  • Open Access
    Modulation of Symbiotic Compatibility by Rhizobial Zinc Starvation Machinery
    Research Article | Host-Microbe Biology
    Modulation of Symbiotic Compatibility by Rhizobial Zinc Starvation Machinery

    The rhizobium-legume symbiosis contributes around 65% of biological nitrogen fixation in agriculture systems and is critical for sustainable agriculture by reducing the amount of chemical nitrogen fertilizer being used. Rhizobial inocula have been commercialized for more than 100 years, but the efficiency of inoculation can vary among legume cultivars, field sites, and years. These long-lasting challenging problems impede the...

    Pan Zhang, Biliang Zhang, Jian Jiao, Shi-Qi Dai, Wen-Xin Chen, Chang-Fu Tian
  • Open Access
    The Immune Protein Calprotectin Impacts <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Metabolism through Zinc Limitation
    Research Article | Host-Microbe Biology
    The Immune Protein Calprotectin Impacts Clostridioides difficile Metabolism through Zinc Limitation

    Clostridioides difficile infection (CDI) is the leading cause of postantibiotic nosocomial infection. Antibiotic therapy can be successful, yet up to one-third of individuals suffer from recurrent infections. Understanding the mechanisms controlling C. difficile colonization is paramount in...

    Christopher A. Lopez, William N. Beavers, Andy Weiss, Reece J. Knippel, Joseph P. Zackular, Walter Chazin, Eric P. Skaar
  • Open Access
    A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions
    Research Article | Clinical Science and Epidemiology
    A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

    Antibiotic resistance is a growing clinical threat. One of the most serious areas of concern is the ability of some bacteria to degrade carbapenems, drugs that are often reserved as last-resort antibiotics. Resistance to carbapenems can be conferred by a large group of related enzymes called metallo-β-lactamases that rely on zinc ions for function and for overall stability. Here, we studied an extensive panel of 45 different metallo-β-...

    Zishuo Cheng, Ben A. Shurina, Christopher R. Bethel, Pei W. Thomas, Steven H. Marshall, Caitlyn A. Thomas, Kundi Yang, Robert L. Kimble, Jonathan S. Montgomery, Matthew G. Orischak, Callie M. Miller, Jordan L. Tennenbaum, Jay C. Nix, David L. Tierney, Walter Fast, Robert A. Bonomo, Richard C. Page, Michael W. Crowder
  • Open Access
    Research Article
    The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity
    Kyle P. Grim, Brian San Francisco, Jana N. Radin, Erin B. Brazel, Jessica L. Kelliher, Paola K. Párraga Solórzano, Philip C. Kim, Christopher A. McDevitt, Thomas E. Kehl-Fie
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