within-host evolution
Research Article | Host-Microbe BiologyStep-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony VariantsWithin-host evolution has been described in many bacterial diseases, and the genetic basis behind the adaptations has stimulated a lot of interest. Yet, the studied adaptations are generally focused on antibiotic resistance and rarely on the adaptation to the environment given by the host, and the potential trade-offs hindering adaptations to each step of the infection are rarely considered.
Research Article | Ecological and Evolutionary ScienceSelection of Bacterial Mutants in Late Infections: When Vector Transmission Trades Off against Growth Advantage in Stationary PhasePathogens can evolve inside their host, and the importance of this mutation-fueled process is increasingly recognized. A disease outcome may indeed depend in part on pathogen adaptations that emerge during infection. It is therefore important to document these adaptations and the conditions that drive them. In our study, we took advantage of the possibility to monitor within-host evolution in the insect pathogen X. nematophila...