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within-host evolution

  • Open Access
    Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants
    Research Article | Host-Microbe Biology
    Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants

    Within-host evolution has been described in many bacterial diseases, and the genetic basis behind the adaptations has stimulated a lot of interest. Yet, the studied adaptations are generally focused on antibiotic resistance and rarely on the adaptation to the environment given by the host, and the potential trade-offs hindering adaptations to each step of the infection are rarely considered.

    Christian Faucher, Vincent Mazana, Marion Kardacz, Nathalie Parthuisot, Jean-Baptiste Ferdy, David Duneau
  • Open Access
    Selection of Bacterial Mutants in Late Infections: When Vector Transmission Trades Off against Growth Advantage in Stationary Phase
    Research Article | Ecological and Evolutionary Science
    Selection of Bacterial Mutants in Late Infections: When Vector Transmission Trades Off against Growth Advantage in Stationary Phase

    Pathogens can evolve inside their host, and the importance of this mutation-fueled process is increasingly recognized. A disease outcome may indeed depend in part on pathogen adaptations that emerge during infection. It is therefore important to document these adaptations and the conditions that drive them. In our study, we took advantage of the possibility to monitor within-host evolution in the insect pathogen X. nematophila...

    Marine C. Cambon, Nathalie Parthuisot, Sylvie Pagès, Anne Lanois, Alain Givaudan, Jean-Baptiste Ferdy
  • Open Access
    Research Article
    Within-Host Evolution of Burkholderia pseudomallei during Chronic Infection of Seven Australasian Cystic Fibrosis Patients
    Linda T. Viberg, Derek S. Sarovich, Timothy J. Kidd, James B. Geake, Scott C. Bell, Bart J. Currie, Erin P. Price
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