Virus Latency

Highly active antiretroviral therapy (HAART) reduces the circulating virus to undetectable levels. Although patients adhering to the HAART regimen have minimal viremia, HIV persists because of the existence of latent but replication-competent proviruses in a very small population of resting memory CD4⁺ T cells (~1 in 10⁶ cells). Latency remains the major obstacle to a functional cure for HIV infection, since the...