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viral population

  • Open Access
    Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses
    Research Article | Ecological and Evolutionary Science
    Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

    With the advent of advanced sequencing technology, studies of RNA viruses have shown that genetic diversity can contribute to both attenuation and virulence and the paradigm is that this is controlled by the error-prone RNA-dependent RNA polymerase (RdRp). Since wild-type yellow fever virus (YFV) strain Asibi has genetic diversity typical of a wild-type RNA virus, while 17D virus vaccine has limited diversity, it provides a unique...

    Natalie D. Collins, Andrew S. Beck, Steven G. Widen, Thomas G. Wood, Stephen Higgs, Alan D. T. Barrett
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