typhoid

  • Open Access
    Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal <em>Salmonella</em>
    Research Article | Clinical Science and Epidemiology
    Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal Salmonella

    In the early 1900s, with mortality of ∼30%, typhoid and paratyphoid (caused by Salmonella Typhi and Paratyphi A) ravaged parts of the world; with improved water, sanitation, and hygiene in resource-rich countries and the advent of antimicrobials, mortality dwindled to <1%. Today, the burden rests disproportionately on South Asia, where the primary means for combatting the disease is antimicrobials.

    Mohammad S. I. Sajib, Arif M. Tanmoy, Yogesh Hooda, Hafizur Rahman, Jason R. Andrews, Denise O. Garrett, Hubert P. Endtz, Samir K. Saha, Senjuti Saha
  • Open Access
    Research Article
    Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins

    Typhoid fever is a severe disease caused by the Gram-negative bacterium Salmonella enterica serovar Typhi. Antibiotic-resistant S. Typhi strains have become increasingly common. Here, we report the first large-scale emergence and spread of a novel extensively drug-resistant (XDR) S. Typhi clone in Sindh, Pakistan. The XDR S. Typhi is resistant to the majority of drugs available for the treatment of...

    Elizabeth J. Klemm, Sadia Shakoor, Andrew J. Page, Farah Naz Qamar, Kim Judge, Dania K. Saeed, Vanessa K. Wong, Timothy J. Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Saleem, Zahra Hasan, Gordon Dougan, Rumina Hasan
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