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transposons

  • Open Access
    Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions
    Research Article | Molecular Biology and Physiology
    Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions

    We lack fundamental understanding of how phage infection influences bacterial gene expression and, consequently, how bacterial responses to phage infection affect the assembly of polymicrobial communities. Using parallel genomic approaches, we have discovered novel transcriptional regulators and metabolic genes that influence phage infection. The integration of whole-genome transcriptomic profiling during phage infection has revealed...

    Anushila Chatterjee, Julia L. E. Willett, Uyen Thy Nguyen, Brendan Monogue, Kelli L. Palmer, Gary M. Dunny, Breck A. Duerkop
  • Open Access
    SpoT Induces Intracellular <em>Salmonella</em> Virulence Programs in the Phagosome
    Research Article | Host-Microbe Biology
    SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome

    Pathogenic bacteria experience nutritional challenges during colonization and infection of mammalian hosts. Binding of the alarmone nucleotide guanosine tetraphosphate (ppGpp) to RNA polymerase coordinates metabolic adaptations and virulence gene transcription, increasing the fitness of diverse Gram-positive and Gram-negative bacteria as well as that of actinomycetes. Gammaproteobacteria such as Salmonella synthesize ppGpp by...

    Liam F. Fitzsimmons, Lin Liu, Sashi Kant, Ju-Sim Kim, James K. Till, Jessica Jones-Carson, Steffen Porwollik, Michael McClelland, Andres Vazquez-Torres
  • Open Access
    Transposon Mutagenesis in <span class="named-content genus-species" id="named-content-1">Chlamydia trachomatis</span> Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
    Research Article | Host-Microbe Biology
    Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer

    Chlamydia trachomatis infections have an immense impact on public health; however, understanding the basic biology and pathogenesis of this organism has been stalled by the limited repertoire of genetic tools. This report describes the successful adaptation of an important tool that has been lacking in Chlamydia studies: transposon mutagenesis. This advance...

    Scott D. LaBrie, Zoë E. Dimond, Kelly S. Harrison, Srishti Baid, Jason Wickstrum, Robert J. Suchland, P. Scott Hefty
  • Open Access
    Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in <em>Pseudomonas putida</em> Lysine Metabolism
    Research Article | Molecular Biology and Physiology
    Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism

    P. putida lysine metabolism can produce multiple commodity chemicals, conferring great biotechnological value. Despite much research, the connection of lysine catabolism to central metabolism in P. putida remained undefined. Here, we used random barcode transposon sequencing to fill the gaps of...

    Mitchell G. Thompson, Jacquelyn M. Blake-Hedges, Pablo Cruz-Morales, Jesus F. Barajas, Samuel C. Curran, Christopher B. Eiben, Nicholas C. Harris, Veronica T. Benites, Jennifer W. Gin, William A. Sharpless, Frederick F. Twigg, Will Skyrud, Rohith N. Krishna, Jose Henrique Pereira, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Adam P. Arkin, Adam M. Deutschbauer, Jay D. Keasling
  • Open Access
    Gene Essentiality Analyzed by <em>In Vivo</em> Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of <em>Candida albicans</em>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida albicans

    Comprehensive understanding of an organism requires that we understand the contributions of most, if not all, of its genes. Classical genetic approaches to this issue have involved systematic deletion of each gene in the genome, with comprehensive sets of mutants available only for very-well-studied model organisms. We took a different approach, harnessing the power of in vivo transposition coupled with deep sequencing to...

    Ella Shtifman Segal, Vladimir Gritsenko, Anton Levitan, Bhawna Yadav, Naama Dror, Jacob L. Steenwyk, Yael Silberberg, Kevin Mielich, Antonis Rokas, Neil A. R. Gow, Reinhard Kunze, Roded Sharan, Judith Berman
  • Open Access
    Research Article
    Transposon Insertion Sequencing Elucidates Novel Gene Involvement in Susceptibility and Resistance to Phages T4 and T7 in Escherichia coli O157
    Lauren A. Cowley, Alison S. Low, Derek Pickard, Christine J. Boinett, Timothy J. Dallman, Martin Day, Neil Perry, David L. Gally, Julian Parkhill, Claire Jenkins, Amy K. Cain
  • Open Access
    Research Article
    Ongoing Transposon-Mediated Genome Reduction in the Luminous Bacterial Symbionts of Deep-Sea Ceratioid Anglerfishes
    Tory A. Hendry, Lindsay L. Freed, Dana Fader, Danté Fenolio, Tracey T. Sutton, Jose V. Lopez
  • Open Access
    Letter to the Editor
    A Cautionary Tale: Tn903 aph, Kanamycin Resistance Redux in the Environment
    Vivian P. W. Miao
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