Tn-seq
Research Article | Molecular Biology and PhysiologyParallel Genomics Uncover Novel Enterococcal-Bacteriophage InteractionsWe lack fundamental understanding of how phage infection influences bacterial gene expression and, consequently, how bacterial responses to phage infection affect the assembly of polymicrobial communities. Using parallel genomic approaches, we have discovered novel transcriptional regulators and metabolic genes that influence phage infection. The integration of whole-genome transcriptomic profiling during phage infection has revealed...
Research Article | Ecological and Evolutionary ScienceHigh-Throughput Analysis of Gene Function in the Bacterial Predator Bdellovibrio bacteriovorusBdellovibrio bacteriovorus is a predatory bacterium that can kill a wide range of Gram-negative bacteria, including many human pathogens. Given the global rise of antibiotic resistance and dearth of new antibiotics discovered in the past 30 years, this predator has potential as an alternative to traditional antibiotics. For many years,...
Research Article | Molecular Biology and PhysiologyA New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop RibosomesFrancisella tularensis is a highly infectious intracellular pathogen that kills more than half of infected humans if left untreated. F. tularensis has also been classified as a potential bioterrorism agent with a great risk for deliberate misuse. Recently, compounds that inhibit ribosome rescue have...
- Research ArticleThe Essential Genome of Escherichia coli K-12
- Research ArticleMolecular Basis of Bacterial Longevity