tissue engineering

  • Open Access
    Binding Heterogeneity of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1
    Research Article | Host-Microbe Biology
    Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

    Cerebral malaria research has been hindered by the inaccessibility of the brain. Here, we have developed an engineered 3D human brain microvessel model that mimics the blood flow rates and architecture of small blood vessels to study how P. falciparum-infected human erythrocytes attach to brain endothelial cells. By studying parasite lines with different...

    Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
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