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tail-anchored

  • Open Access
    Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article | Molecular Biology and Physiology
    Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli

    A subset of membrane proteins is targeted to and inserted into the membrane via a hydrophobic transmembrane domain (TMD) that is positioned at the very C terminus of the protein. The biogenesis of these so-called tail-anchored proteins (TAMPs) has been studied in detail in eukaryotic cells. Various partly redundant pathways were identified, the choice for which depends in part on the hydrophobicity of the TMD. Much less is known about...

    Markus Peschke, Mélanie Le Goff, Gregory M. Koningstein, Norbert O. Vischer, Abbi Abdel-Rehim, Stephen High, Peter van Ulsen, Joen Luirink
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