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stress response

  • Open Access
    Peptidoglycan Remodeling Enables <span class="named-content genus-species" id="named-content-1">Escherichia</span><span class="named-content genus-species" id="named-content-2"> coli</span> To Survive Severe Outer Membrane Assembly Defect
    Research Article | Molecular Biology and Physiology
    Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

    In Gram-negative bacteria, the outer membrane protects the cell against many toxic molecules, and the peptidoglycan layer provides protection against osmotic challenges, allowing bacterial cells to survive in changing environments. Maintaining cell envelope integrity is therefore a question of life or death for a bacterial cell. Here we show that Escherichia coli...

    Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Trypanosoma brucei</span> PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response
    Research Article | Molecular Biology and Physiology
    Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response

    Trypanosoma brucei infection causes human African trypanosomiasis, also known as sleeping sickness, a disease with a nearly 100% fatality rate when untreated. Current drugs are expensive, toxic, and highly impractical to administer, prompting the community to explore various unique aspects of T. brucei...

    Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, Laurie K. Read
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Helicobacter pylori</span> Biofilm Involves a Multigene Stress-Biased Response, Including a Structural Role for Flagella
    Research Article | Molecular Biology and Physiology
    Helicobacter pylori Biofilm Involves a Multigene Stress-Biased Response, Including a Structural Role for Flagella

    Biofilms, communities of bacteria that are embedded in a hydrated matrix of extracellular polymeric substances, pose a substantial health risk and are key contributors to many chronic and recurrent infections. Chronicity and recalcitrant infections are also common features associated with the ulcer-causing human pathogen H. pylori. However, relatively little is known...

    Skander Hathroubi, Julia Zerebinski, Karen M. Ottemann
  • Open Access
    Minireview
    Errors during Gene Expression: Single-Cell Heterogeneity, Stress Resistance, and Microbe-Host Interactions
    Christopher R. Evans, Yongqiang Fan, Kalyn Weiss, Jiqiang Ling
  • Open Access
    Research Article
    Stress-Induced Reorganization of the Mycobacterial Membrane Domain
    Jennifer M. Hayashi, Kirill Richardson, Emily S. Melzer, Steven J. Sandler, Bree B. Aldridge, M. Sloan Siegrist, Yasu S. Morita
  • Open Access
    Observation
    Stable Signal Peptides and the Response to Secretion Stress in Staphylococcus aureus
    Arryn Craney, Floyd E. Romesberg
  • Open Access
    Research Article
    Psp Stress Response Proteins Form a Complex with Mislocalized Secretins in the Yersinia enterocolitica Cytoplasmic Membrane
    Disha Srivastava, Amal Moumene, Josué Flores-Kim, Andrew J. Darwin
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