stress response
Research Article | Molecular Biology and PhysiologymRNA Degradation Rates Are Coupled to Metabolic Status in Mycobacterium smegmatisThe logistics of tuberculosis therapy are difficult, requiring multiple drugs for many months. Mycobacterium tuberculosis survives in part by entering nongrowing states in which it is metabolically less active and thus less susceptible to antibiotics. Basic knowledge on how M. tuberculosis survives...
Research Article | Molecular Biology and PhysiologyPeptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly DefectIn Gram-negative bacteria, the outer membrane protects the cell against many toxic molecules, and the peptidoglycan layer provides protection against osmotic challenges, allowing bacterial cells to survive in changing environments. Maintaining cell envelope integrity is therefore a question of life or death for a bacterial cell. Here we show that Escherichia coli...
Research Article | Molecular Biology and PhysiologyTrypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress ResponseTrypanosoma brucei infection causes human African trypanosomiasis, also known as sleeping sickness, a disease with a nearly 100% fatality rate when untreated. Current drugs are expensive, toxic, and highly impractical to administer, prompting the community to explore various unique aspects of T. brucei...
Research Article | Molecular Biology and PhysiologyHelicobacter pylori Biofilm Involves a Multigene Stress-Biased Response, Including a Structural Role for FlagellaBiofilms, communities of bacteria that are embedded in a hydrated matrix of extracellular polymeric substances, pose a substantial health risk and are key contributors to many chronic and recurrent infections. Chronicity and recalcitrant infections are also common features associated with the ulcer-causing human pathogen H. pylori. However, relatively little is known...
- Research ArticleStress-Induced Reorganization of the Mycobacterial Membrane Domain