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Streptomyces

  • Open Access
    Competition Sensing Changes Antibiotic Production in <em>Streptomyces</em>
    Research Article | Ecological and Evolutionary Science
    Competition Sensing Changes Antibiotic Production in Streptomyces

    Bacteria secrete antibiotics to inhibit their competitors, but the presence of competitors can determine whether these toxins are produced. Here, we study the role of the competitive and resource environment on antibiotic production in Streptomyces, bacteria renowned for their production of antibiotics.

    Sanne Westhoff, Alexander M. Kloosterman, Stephan F. A. van Hoesel, Gilles P. van Wezel, Daniel E. Rozen
  • Open Access
    Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism
    Perspective | Applied and Environmental Science
    Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism

    Microbial natural products, particularly those produced by filamentous Actinobacteria, underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic classes have been discovered since the 1970s, which has exacerbated fears of a postapocalyptic world in which antibiotics have lost their utility. Excitingly, the genome sequencing revolution painted an entirely new picture, one in which an average...

    Paul A. Hoskisson, Ryan F. Seipke
  • Open Access
    A Chemical Counterpunch: <span class="named-content genus-species" id="named-content-1">Chromobacterium violaceum</span> ATCC 31532 Produces Violacein in Response to Translation-Inhibiting Antibiotics
    Research Article | Molecular Biology and Physiology
    A Chemical Counterpunch: Chromobacterium violaceum ATCC 31532 Produces Violacein in Response to Translation-Inhibiting Antibiotics

    Secondary metabolites play important roles in microbial communities, but their natural functions are often unknown and may be more complex than appreciated. While compounds with antibiotic activity are often assumed to underlie microbial competition, they may alternatively act as signal molecules. In either scenario, microorganisms might evolve responses to sublethal concentrations of these metabolites, either to protect themselves from...

    Gabriel L. Lozano, Changhui Guan, Yanzhuan Cao, Bradley R. Borlee, Nichole A. Broderick, Eric V. Stabb, Jo Handelsman
  • Open Access
    Massive Gene Flux Drives Genome Diversity between Sympatric <em>Streptomyces</em> Conspecifics
    Research Article | Ecological and Evolutionary Science
    Massive Gene Flux Drives Genome Diversity between Sympatric Streptomyces Conspecifics

    Horizontal gene transfer is a rapid and efficient way to diversify bacterial gene pools. Currently, little is known about this gene flux within natural soil populations. Using comparative genomics of Streptomyces strains belonging to the same species and isolated at microscale, we reveal frequent transfer of a significant fraction of the pangenome. We show that it occurs at a time scale enabling the population to diversify and...

    Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Maxime Toussaint, Erwin van Dijk, Delphine Naquin, Olivier Lespinet, Cyril Bontemps, Pierre Leblond
  • Open Access
    A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators
    Editor's Pick Research Article | Applied and Environmental Science
    A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators

    Access to whole-genome sequences has exposed the general incidence of the so-called cryptic biosynthetic gene clusters (BGCs), thereby renewing their interest for natural product discovery. As a consequence, genome mining is the often first approach implemented to assess the potential of a microorganism for producing novel bioactive metabolites. By revealing a new level of complexity of natural product biosynthesis, we further...

    Loïc Martinet, Aymeric Naômé, Benoit Deflandre, Marta Maciejewska, Déborah Tellatin, Elodie Tenconi, Nicolas Smargiasso, Edwin de Pauw, Gilles P. van Wezel, Sébastien Rigali
  • Open Access
    Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in <em>Streptomyces coelicolor</em> M145
    Research Article | Molecular Biology and Physiology
    Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145

    Until now, knowledge of the utilization of ethanolamine in Streptomyces was limited. Our work represents the first attempt to reveal a novel ethanolamine utilization pathway in the actinobacterial model organism S. coelicolor through the characterization of the key enzyme gamma-glutamylethanolamide synthetase GlnA4, which is absolutely required for growth in...

    Sergii Krysenko, Arne Matthews, Nicole Okoniewski, Andreas Kulik, Melis G. Girbas, Olga Tsypik, Christian Stephan Meyners, Felix Hausch, Wolfgang Wohlleben, Agnieszka Bera
  • Open Access
    <em>Streptomyces</em> Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability
    Editor's Pick Research Article | Molecular Biology and Physiology
    Streptomyces Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability

    Microbial growth and community interactions are influenced by a multitude of factors. A new mode of Streptomyces growth—exploration—is promoted by interactions with the yeast Saccharomyces cerevisiae and requires the emission of trimethylamine (TMA), a pH-raising volatile compound. We show...

    Stephanie E. Jones, Christine A. Pham, Matthew P. Zambri, Joseph McKillip, Erin E. Carlson, Marie A. Elliot
  • Open Access
    Research Article
    Expanding Primary Metabolism Helps Generate the Metabolic Robustness To Facilitate Antibiotic Biosynthesis in Streptomyces
    Jana K. Schniete, Pablo Cruz-Morales, Nelly Selem-Mojica, Lorena T. Fernández-Martínez, Iain S. Hunter, Francisco Barona-Gómez, Paul A. Hoskisson
  • Open Access
    Research Article
    Translational Control of the SigR-Directed Oxidative Stress Response in Streptomyces via IF3-Mediated Repression of a Noncanonical GTC Start Codon

    In all sigma factor-antisigma factor regulatory switches, the relative abundance of the two proteins is critical to the proper functioning of the system. Many sigma-antisigma operons are cotranscribed and translationally coupled, leading to a generic assumption that the sigma and antisigma factors are produced in a fixed 1:1 ratio. In the case of sigR-rsrA, we show instead that the antisigma factor is produced in...

    Morgan A. Feeney, Govind Chandra, Kim C. Findlay, Mark S. B. Paget, Mark J. Buttner
  • Open Access
    Research Article
    Lateral Gene Transfer Dynamics in the Ancient Bacterial Genus Streptomyces

    Tree-based phylogenetics and the use of species as units of diversity lie at the foundation of modern biology. In bacteria, these pillars of evolutionary theory have been called into question due to the observation of thousands of lateral gene transfer (LGT) events within and between lineages. Here, we show that acquisition and retention of genes through LGT are exceedingly rare in the bacterial genus Streptomyces, with merely...

    Bradon R. McDonald, Cameron R. Currie
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