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Staphylococcus aureus

  • Open Access
    Intracellular <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Perturbs the Host Cell Ca<sup>2+</sup> Homeostasis To Promote Cell Death
    Research Article | Host-Microbe Biology
    Intracellular Staphylococcus aureus Perturbs the Host Cell Ca2+ Homeostasis To Promote Cell Death

    Despite being regarded as an extracellular bacterium, the pathogen Staphylococcus aureus can invade and survive within human cells. The intracellular niche is considered a hideout from the host immune system and antibiotic treatment and allows bacterial proliferation.

    Kathrin Stelzner, Ann-Cathrin Winkler, Chunguang Liang, Aziza Boyny, Carsten P. Ade, Thomas Dandekar, Martin J. Fraunholz, Thomas Rudel
  • Open Access
    Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Research Article | Clinical Science and Epidemiology
    Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

    The majority of Staphylococcus aureus strains causing human disease are methicillin-susceptible (MSSA) and can be treated with antistaphylococcal penicillins (such as oxacillin). While acquisition of the mec gene represents the main resistance mechanism to oxacillin, S. aureus can acquire...

    Stefano G. Giulieri, Romain Guérillot, Jason C. Kwong, Ian R. Monk, Ashleigh S. Hayes, Diane Daniel, Sarah Baines, Norelle L. Sherry, Natasha E. Holmes, Peter Ward, Wei Gao, Torsten Seemann, Timothy P. Stinear, Benjamin P. Howden
  • Open Access
    The Expression of von Willebrand Factor-Binding Protein Determines Joint-Invading Capacity of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>, a Core Mechanism of Septic Arthritis
    Research Article | Host-Microbe Biology
    The Expression of von Willebrand Factor-Binding Protein Determines Joint-Invading Capacity of Staphylococcus aureus, a Core Mechanism of Septic Arthritis

    Septic arthritis remains one of the most dangerous joint diseases with a rapidly progressive disease character. Despite advances in the use of antibiotics, permanent reductions in joint function due to joint deformation and deleterious contractures occur in up to 50% of patients with septic arthritis. So far, it is still largely unknown how S. aureus initiates and...

    Manli Na, Zhicheng Hu, Majd Mohammad, Mariana do Nascimento Stroparo, Abukar Ali, Ying Fei, Anders Jarneborn, Peter Verhamme, Olaf Schneewind, Dominique Missiakas, Tao Jin
  • Open Access
    Population Analysis of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia
    Research Article | Host-Microbe Biology
    Population Analysis of Staphylococcus aureus Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia

    Staphylococcus aureus is an important human and animal pathogen associated with an array of diseases, including life-threatening necrotizing pneumonia and infective endocarditis. The success of S. aureus as a pathogen has been linked in part to its ability to manipulate the host immune response...

    Manouk Vrieling, Stephen W. Tuffs, Gonzalo Yebra, Marleen Y. van Smoorenburg, Joana Alves, Amy C. Pickering, Joo Youn Park, Nogi Park, David E. Heinrichs, Lindert Benedictus, Timothy Connelley, Keun Seok Seo, John K. McCormick, J. Ross Fitzgerald
  • Open Access
    A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens
    Research Article | Host-Microbe Biology
    A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens

    Staphylococcus aureus is a leading agent of antibiotic-resistant bacterial infections in the world. S. aureus tightly controls metal homeostasis during infection, and disruption of metal uptake systems impairs staphylococcal virulence. We identified small molecules that interfere with metal handling...

    Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
  • Open Access
    Identification of a Novel LysR-Type Transcriptional Regulator in <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection
    Research Article | Host-Microbe Biology
    Identification of a Novel LysR-Type Transcriptional Regulator in Staphylococcus aureus That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection

    Staphylococcus aureus is an important pathogen that can disseminate via the bloodstream and establish metastatic infections in distant organs. To achieve a better understanding of the bacterial factors facilitating the development of these metastatic infections, we used in this study a Staphylococcus...

    Michaela Groma, Sarah A. Horst, Sudip Das, Bruno Huettel, Maximilian Klepsch, Thomas Rudel, Eva Medina, Martin Fraunholz
  • Open Access
    Lipoprotein <em>N</em>-Acylation in <em>Staphylococcus aureus</em> Is Catalyzed by a Two-Component Acyl Transferase System
    Research Article | Molecular Biology and Physiology
    Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System

    Although it has long been known that S. aureus forms triacylated Lpps, a lack of homologs to known N-acylation genes found in Gram-negative bacteria has until now precluded identification of the genes responsible for this Lpp modification. Here, we demonstrate N-terminal Lpp acylation and chemotype conversion to the tri-acylated state is directed by a unique...

    John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Lipase 1 Enhances Influenza A Virus Replication
    Research Article | Host-Microbe Biology
    Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication

    Influenza A virus (IAV) causes annual epidemics and sporadic pandemics of respiratory disease. Secondary bacterial coinfection by organisms such as Staphylococcus aureus is the most common complication of primary IAV infection and is associated with high levels of morbidity and mortality. Here, we report the first identified...

    Mariya I. Goncheva, Carina Conceicao, Stephen W. Tuffs, Hui-Min Lee, Marlynne Quigg-Nicol, Ian Bennet, Fiona Sargison, Amy C. Pickering, Saira Hussain, Andrew C. Gill, Bernadette M. Dutia, Paul Digard, J. Ross Fitzgerald
  • Open Access
    Genotypic and Phenotypic Diversity of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Isolates from Cystic Fibrosis Patient Lung Infections and Their Interactions with <span class="named-content genus-species" id="named-content-2">Pseudomonas aeruginosa</span>
    Research Article | Host-Microbe Biology
    Genotypic and Phenotypic Diversity of Staphylococcus aureus Isolates from Cystic Fibrosis Patient Lung Infections and Their Interactions with Pseudomonas aeruginosa

    Staphylococcus aureus is now the most frequently detected recognized pathogen in the lungs of individuals who have cystic fibrosis (CF) in the United States, followed closely by Pseudomonas aeruginosa. When these pathogens are found to coinfect the CF lung, patients have a significantly worse...

    Eryn E. Bernardy, Robert A. Petit, Vishnu Raghuram, Ashley M. Alexander, Timothy D. Read, Joanna B. Goldberg
  • Open Access
    Convergent Evolution of Neutralizing Antibodies to <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> γ-Hemolysin C That Recognize an Immunodominant Primary Sequence-Dependent B-Cell Epitope
    Research Article | Therapeutics and Prevention
    Convergent Evolution of Neutralizing Antibodies to Staphylococcus aureus γ-Hemolysin C That Recognize an Immunodominant Primary Sequence-Dependent B-Cell Epitope

    Staphylococcus aureus infection is a major public health threat in part due to the spread of antibiotic resistance and repeated failures to develop a protective vaccine. Infection is associated with production of virulence factors that include exotoxins that attack host barriers and cellular defenses, such as the leukocidin (Luk) family of bicomponent pore-forming...

    David N. Hernandez, Kayan Tam, Bo Shopsin, Emily E. Radke, Karen Law, Timothy Cardozo, Victor J. Torres, Gregg J. Silverman

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