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specialized metabolism

  • Open Access
    Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism
    Perspective | Applied and Environmental Science
    Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism

    Microbial natural products, particularly those produced by filamentous Actinobacteria, underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic classes have been discovered since the 1970s, which has exacerbated fears of a postapocalyptic world in which antibiotics have lost their utility. Excitingly, the genome sequencing revolution painted an entirely new picture, one in which an average...

    Paul A. Hoskisson, Ryan F. Seipke
  • Open Access
    Cooperation, Competition, and Specialized Metabolism in a Simplified Root Nodule Microbiome
    Research Article | Ecological and Evolutionary Science
    Cooperation, Competition, and Specialized Metabolism in a Simplified Root Nodule Microbiome

    Microbiomes associated with various plant structures often contain members with the potential to make specialized metabolites, e.g., molecules with antibacterial, antifungal, or siderophore activities. However, when and where microbes associated with plants produce specialized metabolites, and the potential role of these molecules in mediating intramicrobiome interactions, is not well understood. Root nodules of legume plants are organs...

    Bridget L. Hansen, Rita de Cassia Pessotti, Monika S. Fischer, Alyssa Collins, Laila El-Hifnawi, Mira D. Liu, Matthew F. Traxler
  • Open Access
    Gliotoxin, a Known Virulence Factor in the Major Human Pathogen <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>, Is Also Biosynthesized by Its Nonpathogenic Relative <em>Aspergillus fischeri</em>
    Observation | Ecological and Evolutionary Science
    Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri

    Aspergillus fumigatus is a major opportunistic fungal pathogen of humans, but most of its close relatives are nonpathogenic. Why is that so? This important, yet largely unanswered, question can be addressed by examining how A. fumigatus and its close nonpathogenic relatives are similar or different...

    Sonja L. Knowles, Matthew E. Mead, Lilian Pereira Silva, Huzefa A. Raja, Jacob L. Steenwyk, Gustavo H. Goldman, Nicholas H. Oberlies, Antonis Rokas
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