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signal transduction

  • Open Access
    <em>Plasmodium falciparum</em> Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress
    Research Article | Host-Microbe Biology
    Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

    The clinical manifestations of malaria arise due to successive rounds of replication of Plasmodium parasites within red blood cells. Once mature, daughter merozoites are released from infected erythrocytes to invade new cells in a tightly regulated process termed egress.

    Stephanie D. Nofal, Avnish Patel, Michael J. Blackman, Christian Flueck, David A. Baker
  • Open Access
    The Unconventional Cytoplasmic Sensing Mechanism for Ethanol Chemotaxis in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span>
    Research Article | Molecular Biology and Physiology
    The Unconventional Cytoplasmic Sensing Mechanism for Ethanol Chemotaxis in Bacillus subtilis

    Ethanol is a chemoattractant for Bacillus subtilis even though it is not metabolized and inhibits growth. B. subtilis likely uses ethanol to find ethanol-fermenting microorganisms to utilize as prey. Two chemoreceptors sense ethanol: HemAT and McpB. HemAT’s myoglobin-like sensing domain directly...

    Payman Tohidifar, Girija A. Bodhankar, Sichong Pei, C. Keith Cassidy, Hanna E. Walukiewicz, George W. Ordal, Phillip J. Stansfeld, Christopher V. Rao
  • Open Access
    Cyclic di-GMP Signaling in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Is Governed by Direct Interactions of Diguanylate Cyclases and Cognate Receptors
    Research Article | Molecular Biology and Physiology
    Cyclic di-GMP Signaling in Bacillus subtilis Is Governed by Direct Interactions of Diguanylate Cyclases and Cognate Receptors

    Second messengers are free to diffuse through the cells and to activate all responsive elements. Cyclic di-GMP (c-di-GMP) signaling plays an important role in the determination of the life style transition between motility and sessility/biofilm formation but involves numerous distinct synthetases (diguanylate cyclases [DGCs]) or receptor pathways that appear to act in an independent manner. Using...

    Sandra Kunz, Anke Tribensky, Wieland Steinchen, Luis Oviedo-Bocanegra, Patricia Bedrunka, Peter L. Graumann
  • Open Access
    How Bacterial Chemoreceptors Evolve Novel Ligand Specificities
    Editor's Pick Research Article | Molecular Biology and Physiology
    How Bacterial Chemoreceptors Evolve Novel Ligand Specificities

    Many bacteria possess a large number of chemoreceptors that recognize a variety of different compounds. More than 60% of the genomes analyzed in this study contain paralogous chemoreceptors, suggesting that they emerge with high frequency. We provide first insight on how paralogous receptors have evolved and show that two chemoreceptors with a narrow ligand range have evolved from an ancestral protein with a broad chemoeffector spectrum...

    José Antonio Gavira, Vadim M. Gumerov, Miriam Rico-Jiménez, Marharyta Petukh, Amit A. Upadhyay, Alvaro Ortega, Miguel A. Matilla, Igor B. Zhulin, Tino Krell
  • Open Access
    Comprehensive Analysis of <span class="named-content genus-species" id="named-content-1">Aspergillus nidulans</span> PKA Phosphorylome Identifies a Novel Mode of CreA Regulation
    Research Article | Molecular Biology and Physiology
    Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

    The cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling pathway is well conserved across eukaryotes, and previous work has shown that it plays an important role in regulating development, growth, and virulence in a number of fungi. PKA is activated in response to extracellular nutrients and acts to regulate metabolism and growth. While a number of components in the PKA pathway have been defined in filamentous fungi, current...

    Liliane F. C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik, Simin Hossain, Jessica J. J. Ramsey, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. de Assis, Mevlut Ulas, Ozgur Bayram, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Marten
  • Open Access
    Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation
    Research Article | Molecular Biology and Physiology
    Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation

    In many bacteria, two or more homologous chemosensory pathways control several cellular functions, such as motility and gene regulation, in response to changes in the cell’s microenvironment. Cross talk between signal transduction systems is poorly understood; while generally it is considered to be undesired, in some instances it might be beneficial for coregulation of complex behaviors. We demonstrate that several receptors from the...

    Zhou Huang, Yun-Hao Wang, Hai-Zhen Zhu, Ekaterina P. Andrianova, Cheng-Ying Jiang, Defeng Li, Luyan Ma, Jie Feng, Zhi-Pei Liu, Hua Xiang, Igor B. Zhulin, Shuang-Jiang Liu
  • Open Access
    Research Article
    Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
    Xavier Carette, John Platig, David C. Young, Michaela Helmel, Albert T. Young, Zhe Wang, Lakshmi-Prasad Potluri, Cameron Stuver Moody, Jumei Zeng, Sladjana Prisic, Joseph N. Paulson, Jan Muntel, Ashoka V. R. Madduri, Jorge Velarde, Jacob A. Mayfield, Christopher Locher, Tiansheng Wang, John Quackenbush, Kyu Y. Rhee, D. Branch Moody, Hanno Steen, Robert N. Husson
  • Open Access
    Research Article
    Proposed Role for KaiC-Like ATPases as Major Signal Transduction Hubs in Archaea

    Little is currently known about signal transduction pathways in Archaea. Recent studies indicate that KaiC-like ATPases, known as key components of the circadian clock apparatus in cyanobacteria, are involved in the regulation of archaellum assembly and, likely, type IV pili and the gas vesicle system in Archaea. We performed comprehensive comparative genomic analyses of the KaiC family. A vast protein interaction...

    Kira S. Makarova, Michael Y. Galperin, Eugene V. Koonin
  • Open Access
    Research Article
    Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection
    Benjamin A. Krishna, Emma L. Poole, Sarah E. Jackson, Martine J. Smit, Mark R. Wills, John H. Sinclair
  • Open Access
    Research Article
    An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans
    Mélanie Tanguy, Louise Véron, Przemyslaw Stempor, Julie Ahringer, Peter Sarkies, Eric A. Miska

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