RLR/MAVS signaling pathway

  • Open Access
    Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
    Research Article | Host-Microbe Biology
    Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

    HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help...

    Xuefeng Jiang, Tian Tang, Jinfeng Guo, Yuhang Wang, Peipei Li, Xiangjun Chen, Lily Wang, Yiqun Wen, Junli Jia, Garbarino Emanuela, Benshun Hu, Shuhua Chen, Kun Yao, Linyun Li, Huaming Tang
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