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rifampin

  • Open Access
    Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth
    Research Article | Molecular Biology and Physiology
    Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth

    All mycobacteria encode a group II sigma factor, σB, closely related to the group I principal housekeeping sigma factor, σA. Group II sigma factors are widely believed to play specialized roles in the general stress response and stationary-phase transition in the bacteria that encode them. Contrary to this widely accepted view, we show an additional housekeeping function of σB that complements the...

    Kelley Hurst-Hess, Rajesh Biswas, Yong Yang, Paulami Rudra, Erica Lasek-Nesselquist, Pallavi Ghosh
  • Open Access
    Differentially Detectable <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment
    Research Article | Therapeutics and Prevention
    Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment

    Measurement of the reduction in CFU in sputum of patients with TB up to 2 weeks after the initiation of treatment is the gateway test for a new TB treatment. Reports have suggested that CFU assays fail to detect the majority of viable M. tuberculosis cells in sputum samples from the majority of patients when the number of...

    Kathrine McAulay, Kohta Saito, Thulasi Warrier, Kathleen Frances Walsh, Laurent Daniel Mathurin, Gertrude Royal-Mardi, Myung Hee Lee, Oksana Ocheretina, Jean William Pape, Daniel W. Fitzgerald, Carl F. Nathan
  • Open Access
    Research Article
    The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing
    Soumitesh Chakravorty, Ann Marie Simmons, Mazhgan Rowneki, Heta Parmar, Yuan Cao, Jamie Ryan, Padmapriya P. Banada, Srinidhi Deshpande, Shubhada Shenai, Alexander Gall, Jennifer Glass, Barry Krieswirth, Samuel G. Schumacher, Pamela Nabeta, Nestani Tukvadze, Camilla Rodrigues, Alena Skrahina, Elisa Tagliani, Daniela M. Cirillo, Amy Davidow, Claudia M. Denkinger, David Persing, Robert Kwiatkowski, Martin Jones, David Alland
  • Open Access
    Research Article
    Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing
    Sarah B. Namugenyi, Alisha M. Aagesen, Sarah R. Elliott, Anna D. Tischler
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