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Pseudomonas aeruginosa

  • Open Access
    Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Pulmonary Infection
    Research Article
    Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

    Pseudomonas aeruginosa pulmonary infection can lead to exaggerated neutrophilic inflammation and tissue destruction, yet host factors that regulate the neutrophilic response is not fully known. IL-36γ is a proinflammatory cytokine that dramatically increases in bioactivity following N-terminal processing by proteases.

    Hernán F. Peñaloza, Tolani F. Olonisakin, William G. Bain, Yanyan Qu, Rick van der Geest, Jill Zupetic, Mei Hulver, Zeyu Xiong, Michael W. Newstead, Chunbin Zou, Jonathan K. Alder, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee
  • Open Access
    A <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Antimicrobial Affects the Biogeography but Not Fitness of <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span> during Coculture
    Research Article
    A Pseudomonas aeruginosa Antimicrobial Affects the Biogeography but Not Fitness of Staphylococcus aureus during Coculture

    Many human infections result from the action of multispecies bacterial communities. Within these communities, bacteria have been proposed to directly interact via physical and chemical means, resulting in increased disease and antimicrobial tolerance.

    Juan P. Barraza, Marvin Whiteley
  • Open Access
    Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Molecular Biology and Physiology
    Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa

    HtrA-family proteases are commonly employed to sense the protein folding stress and activate the regulated intramembrane proteolysis (RIP) cascade in Gram-negative bacteria. Here, we reveal the unique dual-signal activation and dynamic regulation properties of AlgW, an HtrA-type protease triggering the AlgU stress-response pathway, which controls alginate production and mucoid conversion in...

    Tao Li, Yingjie Song, Liming Luo, Ninglin Zhao, Lihui He, Mei Kang, Changcheng Li, Yibo Zhu, Yalin Shen, Chang Zhao, Jing Yang, Qin Huang, Xingyu Mou, Zhiyong Zong, Jinliang Yang, Hong Tang, Yongxing He, Rui Bao
  • Open Access
    Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Therapeutics and Prevention
    Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

    Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.

    Malligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H. Marshall, Krisztina M. Papp-Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A. Bonomo, Focco van den Akker
  • Open Access
    How Phagocytic Cells Kill Different Bacteria: a Quantitative Analysis Using <span class="named-content genus-species" id="named-content-1">Dictyostelium discoideum</span>
    Editor's Pick Research Article | Host-Microbe Biology
    How Phagocytic Cells Kill Different Bacteria: a Quantitative Analysis Using Dictyostelium discoideum

    Phagocytic cells ingest and kill bacteria, a process essential for the defense of the human body against infections. Many potential killing mechanisms have been identified in phagocytic cells, including free radicals, toxic ions, enzymes, and permeabilizing peptides.

    Tania Jauslin, Otmane Lamrabet, Xenia Crespo-Yañez, Anna Marchetti, Imen Ayadi, Estelle Ifrid, Cyril Guilhen, Matthias Leippe, Pierre Cosson
  • Open Access
    A Grad-seq View of RNA and Protein Complexes in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> under Standard and Bacteriophage Predation Conditions
    Research Article | Molecular Biology and Physiology
    A Grad-seq View of RNA and Protein Complexes in Pseudomonas aeruginosa under Standard and Bacteriophage Predation Conditions

    Stable complexes by cellular proteins and RNA molecules lie at the heart of gene regulation and physiology in any bacterium of interest. It is therefore crucial to globally determine these complexes in order to identify and characterize new molecular players and regulation mechanisms.

    Milan Gerovac, Laura Wicke, Kotaro Chihara, Cornelius Schneider, Rob Lavigne, Jörg Vogel
  • Open Access
    Predictive Rules of Efflux Inhibition and Avoidance in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Therapeutics and Prevention
    Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa

    Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps remain poorly understood. We identified properties that correlate with efflux avoidance and inhibition, are predictive of similar features in structurally diverse compounds, and allow...

    Jitender Mehla, Giuliano Malloci, Rachael Mansbach, Cesar A. López, Ruslan Tsivkovski, Keith Haynes, Inga V. Leus, Sally B. Grindstaff, Robert H. Cascella, Napoleon D’Cunha, Liam Herndon, Nicolas W. Hengartner, Enrico Margiotta, Alessio Atzori, Attilio V. Vargiu, Pedro D. Manrique, John K. Walker, Olga Lomovskaya, Paolo Ruggerone, S. Gnanakaran, Valentin V. Rybenkov, Helen I. Zgurskaya
  • Open Access
    Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> <em>In Vitro</em> and <em>In Vivo</em>
    Editor's Pick Research Article | Therapeutics and Prevention
    Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

    Numerous Gram-negative bacteria are becoming increasingly resistant to multiple, if not all, classes of existing antibiotics. Multidrug-resistant Pseudomonas aeruginosa bacteria are a major cause of health care-associated infections in a variety of clinical settings, endangering patients who are immunocompromised or those who suffer from chronic infections, such as...

    Dina A. Moustafa, Ashley W. Wu, Danniel Zamora, Seth M. Daly, Carolyn R. Sturge, Christine Pybus, Bruce L. Geller, Joanna B. Goldberg, David E. Greenberg
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin
    Research Article | Host-Microbe Biology
    Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin

    Kaposi’s sarcoma (KS), caused by infection with Kaposi’s sarcoma-associated herpesvirus (KSHV), is one of the most common cancers in AIDS patients. KS is a highly inflammatory tumor, but how KSHV infection induces inflammation remains unclear. We have previously shown that KSHV infection upregulates Toll-like receptor 4 (TLR4), sensitizing cells to lipopolysaccharide (LPS) and...

    Ashley Markazi, Paige M. Bracci, Michael McGrath, Shou-Jiang Gao
  • Open Access
    Gene Loss and Acquisition in Lineages of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Evolving in Cystic Fibrosis Patient Airways
    Research Article | Host-Microbe Biology
    Gene Loss and Acquisition in Lineages of Pseudomonas aeruginosa Evolving in Cystic Fibrosis Patient Airways

    Bacterial airway infections, predominantly caused by P. aeruginosa, are a major cause of mortality and morbidity of CF patients. While short insertions and deletions as well as point mutations occurring during infection are well studied, there is a lack of understanding of how gene loss and acquisition play roles in bacterial adaptation to the human airways. Here, we...

    Migle Gabrielaite, Helle K. Johansen, Søren Molin, Finn C. Nielsen, Rasmus L. Marvig

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