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Protein Processing, Post-Translational

  • Open Access
    Research Article
    Ancient Regulatory Role of Lysine Acetylation in Central Metabolism

    Post-translational modifications can regulate the activity and localization of proteins inside the cell. Similar to phosphorylation, lysine acetylation is present in both eukaryotes and prokaryotes and modifies hundreds to thousands of proteins in cells. However, how lysine acetylation regulates protein function and whether such a mechanism is evolutionarily conserved is still poorly understood. Here, we investigated evolutionary and...

    Ernesto S. Nakayasu, Meagan C. Burnet, Hanna E. Walukiewicz, Christopher S. Wilkins, Anil K. Shukla, Shelby Brooks, Matthew J. Plutz, Brady D. Lee, Birgit Schilling, Alan J. Wolfe, Susanne Müller, John R. Kirby, Christopher V. Rao, John R. Cort, Samuel H. Payne
  • Open Access
    Research Article
    Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

    Highly active antiretroviral therapy (HAART) reduces the circulating virus to undetectable levels. Although patients adhering to the HAART regimen have minimal viremia, HIV persists because of the existence of latent but replication-competent proviruses in a very small population of resting memory CD4+ T cells (~1 in 106 cells). Latency remains the major obstacle to a functional cure for HIV infection, since the...

    Kien Nguyen, Biswajit Das, Curtis Dobrowolski, Jonathan Karn
  • Open Access
    Research Article
    A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus

    Our understanding of signal transduction networks in pathogenic fungi is limited, despite the increase in invasive fungal infections and rising mortality rates in the immunosuppressed patient population. Because PKA is known to be essential for hyphal growth and virulence of A. fumigatus, we sought to identify fungus-specific regulatory mechanisms governing PKA activity. In this study, we identify, for the first time, a novel...

    E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Erik J. Soderblom, M. Arthur Moseley, Nathan I. Nicely, Yohannes G. Asfaw, William J. Steinbach
  • Open Access
    Research Article
    Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes

    Pyroglutamate modification is the post-translational conversion of N-terminal glutamine or glutamate into a cyclized amino acid derivative. This modification is well studied in animal systems but poorly explored in fungal systems. In Neurospora crassa, we show that this modification takes place in the ER and is catalyzed by two well-conserved enzymes, ubiquitously conserved throughout the fungal kingdom. We demonstrate that the...

    Vincent W. Wu, Craig M. Dana, Anthony T. Iavarone, Douglas S. Clark, N. Louise Glass
  • Open Access
    Research Article
    Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
    David Ribet, Valérie Lallemand-Breitenbach, Omar Ferhi, Marie-Anne Nahori, Hugo Varet, Hugues de Thé, Pascale Cossart
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