protein acetylation

  • Open Access
    Research Article
    Ancient Regulatory Role of Lysine Acetylation in Central Metabolism

    Post-translational modifications can regulate the activity and localization of proteins inside the cell. Similar to phosphorylation, lysine acetylation is present in both eukaryotes and prokaryotes and modifies hundreds to thousands of proteins in cells. However, how lysine acetylation regulates protein function and whether such a mechanism is evolutionarily conserved is still poorly understood. Here, we investigated evolutionary and...

    Ernesto S. Nakayasu, Meagan C. Burnet, Hanna E. Walukiewicz, Christopher S. Wilkins, Anil K. Shukla, Shelby Brooks, Matthew J. Plutz, Brady D. Lee, Birgit Schilling, Alan J. Wolfe, Susanne Müller, John R. Kirby, Christopher V. Rao, John R. Cort, Samuel H. Payne
  • Open Access
    Research Article
    A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase

    During host infection, pathogenic bacteria can modulate their physiology to evade host defenses. Some pathogens use toxin-antitoxin systems to modulate a state of self-toxicity that can decrease their cellular activity, triggering the onset of a persister state. The lower metabolic activity of persister cells allows them to escape host defenses and antibiotic treatments. Hence a better understanding of the mechanisms used by pathogens...

    Chelsey M. VanDrisse, Anastacia R. Parks, Jorge C. Escalante-Semerena
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