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ppGpp

  • Open Access
    Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article | Molecular Biology and Physiology
    Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli

    How do bacterial cells grow without breaking their membranes? Although the biochemistry of fatty acid and membrane synthesis is well known, how membrane synthesis is balanced with growth and metabolism has remained unclear. This is partly due to the many control points that have been discovered within the membrane synthesis pathways. By precisely establishing the contributions of individual pathway enzymes, our results simplify the...

    Marek J. Noga, Ferhat Büke, Niels J. F. van den Broek, Nicole C. E. Imholz, Nicole Scherer, Flora Yang, Gregory Bokinsky
  • Open Access
    Tailoring a Global Iron Regulon to a Uropathogen
    Editor's Pick Research Article | Molecular Biology and Physiology
    Tailoring a Global Iron Regulon to a Uropathogen

    Host iron restriction is a common mechanism for limiting the growth of pathogens. We compared the regulatory network controlled by Fur in uropathogenic E. coli (UPEC) to that of nonpathogenic E. coli K-12 to uncover strategies that pathogenic bacteria use to overcome iron limitation. Although iron...

    Rajdeep Banerjee, Erin Weisenhorn, Kevin J. Schwartz, Kevin S. Myers, Jeremy D. Glasner, Nicole T. Perna, Joshua J. Coon, Rodney A. Welch, Patricia J. Kiley
  • Open Access
    The Absence of (p)ppGpp Renders Initiation of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Chromosomal DNA Synthesis Independent of Growth Rates
    Editor's Pick Research Article | Molecular Biology and Physiology
    The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates

    Bacterial cells regulate their own chromosomal DNA synthesis and cell division depending on the growth conditions, producing more DNA when growing in nutritionally rich media than in poor media (i.e., human gut versus water reservoir). The accumulation of the nucleotide analog (p)ppGpp is usually viewed as serving to warn cells of impending peril due to otherwise lethal sources of stress, which stops growth and inhibits DNA, RNA, and...

    Llorenç Fernández-Coll, Monika Maciag-Dorszynska, Krishma Tailor, Stephen Vadia, Petra Anne Levin, Agnieszka Szalewska-Palasz, Michael Cashel
  • Open Access
    The Stringent Response Inhibits DNA Replication Initiation in <span class="named-content genus-species" id="named-content-1">E. coli</span> by Modulating Supercoiling of <em>oriC</em>
    Research Article | Molecular Biology and Physiology
    The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

    To survive bouts of starvation, cells must inhibit DNA replication. In bacteria, starvation triggers production of a signaling molecule called ppGpp (guanosine tetraphosphate) that helps reprogram cellular physiology, including inhibiting new rounds of DNA replication. While ppGpp has been known to block replication initiation in Escherichia coli for decades, the...

    James A. Kraemer, Allen G. Sanderlin, Michael T. Laub
  • Open Access
    Serine-Threonine Kinases Encoded by Split <em>hipA</em> Homologs Inhibit Tryptophanyl-tRNA Synthetase
    Research Article | Molecular Biology and Physiology
    Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

    Bacterial toxin-antitoxin (TA) modules confer multidrug tolerance (persistence) that may contribute to the recalcitrance of chronic and recurrent infections. The first high-persister gene identified was hipA of Escherichia coli strain K-12, which encodes a kinase that inhibits glutamyl-tRNA synthetase. The hipA gene encodes the toxin of the hipBA...

    Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
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