phase separation

  • Open Access
    Research Article
    Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments

    RNA viruses compartmentalize their replication machinery to evade detection by host pattern recognition receptors and concentrate the machinery of RNA synthesis. For positive-strand RNA viruses, RNA replication occurs in a virus-induced membrane-associated replication organelle. For NNS RNA viruses, the replication compartment is a cytoplasmic inclusion that is not circumscribed by a cellular membrane. Such structures were first...

    Bianca S. Heinrich, Zoltan Maliga, David A. Stein, Anthony A. Hyman, Sean P. J. Whelan
Back to top