phagosome
Minireview | Host-Microbe BiologyVomocytosis: Too Much Booze, Base, or Calcium?Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules. However, some pathogenic agents have the ability to evade this endosomal degradation through a nonlytic exocytosis process termed vomocytosis.
Commentary | Host-Microbe BiologyIn Fungal Intracellular Pathogenesis, Form Determines FateFor pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity.
- Editor's Pick Research Article | Host-Microbe BiologyCandida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization
C. albicans is the most common cause of nosocomial fungal infection, and over 3 million people acquire life-threatening invasive fungal infections every year. Even if antifungal drugs exist, almost half of these patients will die. Despite this, fungi remain underestimated as pathogens. Our study uses quantitative biophysical approaches to demonstrate that yeast-to-...