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persister cells

  • Open Access
    Direct Observation of the Dynamics of Single-Cell Metabolic Activity during Microbial Diauxic Growth
    Observation | Applied and Environmental Science
    Direct Observation of the Dynamics of Single-Cell Metabolic Activity during Microbial Diauxic Growth

    Understanding how genetic information is realized as the behavior of individual cells is a long-term goal of biology but represents a significant technological challenge. In clonal microbial populations, variation in gene regulation is often interpreted as metabolic heterogeneity. This follows the central dogma of biology, in which information flows from DNA to RNA to protein and ultimately manifests as activity. At present, DNA and RNA...

    H. L. O. McClelland, C. Jones, L. M. Chubiz, D. A. Fike, A. S. Bradley
  • Open Access
    Observation
    Cyclic AMP Regulates Bacterial Persistence through Repression of the Oxidative Stress Response and SOS-Dependent DNA Repair in Uropathogenic Escherichia coli
    Roberto C. Molina-Quiroz, Cecilia Silva-Valenzuela, Jennifer Brewster, Eduardo Castro-Nallar, Stuart B. Levy, Andrew Camilli
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