persister cells
Observation | Applied and Environmental ScienceDirect Observation of the Dynamics of Single-Cell Metabolic Activity during Microbial Diauxic GrowthUnderstanding how genetic information is realized as the behavior of individual cells is a long-term goal of biology but represents a significant technological challenge. In clonal microbial populations, variation in gene regulation is often interpreted as metabolic heterogeneity. This follows the central dogma of biology, in which information flows from DNA to RNA to protein and ultimately manifests as activity. At present, DNA and RNA...