peptides

  • Open Access
    <em>De Novo</em> Emergence of Peptides That Confer Antibiotic Resistance
    Editor's Pick Research Article | Ecological and Evolutionary Science
    De Novo Emergence of Peptides That Confer Antibiotic Resistance

    De novo gene origination from nonfunctional DNA sequences was long assumed to be implausible. However, recent studies have shown that large fractions of genomic noncoding DNA are transcribed and translated, potentially generating new genes. Experimental validation of this process so far has been limited to comparative genomics, in vitro selections, or partial randomizations. Here, we describe selection of novel...

    Michael Knopp, Jonina S. Gudmundsdottir, Tobias Nilsson, Finja König, Omar Warsi, Fredrika Rajer, Pia Ädelroth, Dan I. Andersson
  • Open Access
    Research Article
    Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB
    Jason L. Larabee, Sarah J. Bland, Jonathan J. Hunt, Jimmy D. Ballard
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