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penicillin

  • Open Access
    Could Dampening Expression of the <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> <em>mtrCDE</em>-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?
    Research Article | Therapeutics and Prevention
    Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?

    The emergence of gonococcal strains resistant to past or currently used antibiotics is a global public health concern, given the estimated 78 million infections that occur annually. The dearth of new antibiotics to treat gonorrhea demands that alternative curative strategies be considered to counteract antibiotic resistance expressed by gonococci. Herein, we show that decreased expression of a drug efflux pump that participates in...

    Shaochun Chen, Kristie L. Connolly, Corinne Rouquette-Loughlin, Alexander D’Andrea, Ann E. Jerse, William M. Shafer
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