papillomavirus
Research Article | Molecular Biology and PhysiologyHistone Modifications in Papillomavirus Virion MinichromosomesA relatively unique feature of papillomaviruses is that the viral genome is associated with host histones inside the virion. However, little is known about the nature of the epigenome within papillomavirions or its biological relevance to the infectious viral cycle.
Research Article | Host-Microbe BiologyAn Infection-Based Murine Model for Papillomavirus-Associated Head and Neck CancerThe species specificity of papillomavirus has limited the development of an infection-based animal model to study HPV-associated head and neck carcinogenesis. Our study presents a novel in vivo model using the mouse papillomavirus MmuPV1 to study papillomavirus-associated head and neck cancer. In our model, MmuPV1 infects and causes lesions in both immunodeficient and genetically immunocompetent strains of mice. These virally...
Editor's Pick Research Article | Host-Microbe BiologyA Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive TractTractable and efficient models of papillomavirus-induced pathogenesis are limited due to the strict species-specific and tissue-specific tropism of these viruses. Here, we report a novel preclinical murine model of papillomavirus-induced cervicovaginal disease in wild-type, immunocompetent mice using the recently discovered murine papillomavirus, MmuPV1. In this model, MmuPV1 establishes persistent viral infections in the mucosal...
- Research ArticlePersistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer
Human papillomaviruses infect cutaneous and mucosal epithelial cells of the host, and this results in very-long-lived, persistent infection. The viral genomes are small, circular, double-stranded DNA molecules that replicate extrachromosomally in concert with cellular DNA. This replication strategy requires that the virus has a robust mechanism to partition and retain the viral genomes in dividing cells. This has been difficult to study...