nested biosynthetic pathway
Research Article | Molecular Biology and PhysiologyMonasone Naphthoquinone Biosynthesis and Resistance in Monascus FungiThe genes for Monascus naphthoquinone (monasone) biosynthesis are embedded in and form a composite supercluster with the Monascus azaphilone pigment biosynthetic gene cluster. Early biosynthetic intermediates are shared by the two pathways. Some enzymes encoded by the supercluster play double duty in contributing to both pathways, while others are specific for one or the other pathway. The monasone subcluster is...