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multidrug resistance

  • Open Access
    Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> ST258
    Research Article | Therapeutics and Prevention
    Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258

    Infections caused by multidrug-resistant K. pneumoniae pose a serious threat to at-risk patients and present a therapeutic challenge for clinicians. Bacteriophage (phage) therapy is an alternative treatment approach that has been associated with positive clinical outcomes when administered experimentally to patients with refractory bacterial infections.

    ...
    Shayla Hesse, Natalia Malachowa, Adeline R. Porter, Brett Freedman, Scott D. Kobayashi, Donald J. Gardner, Dana P. Scott, Sankar Adhya, Frank R. DeLeo
  • Open Access
    Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates
    Research Article | Molecular Biology and Physiology
    Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

    Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant Gram-negative pathogens. The prevalent AdeB multidrug efflux pump mediates resistance to a broad spectrum of clinically relevant antimicrobial agents.

    Christopher E. Morgan, Przemyslaw Glaza, Inga V. Leus, Anhthu Trinh, Chih-Chia Su, Meng Cui, Helen I. Zgurskaya, Edward W. Yu
  • Open Access
    Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract
    Research Article | Therapeutics and Prevention
    Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

    Invasive pathobionts or microbes capable of causing disease can reside deep within the mucosal epithelium of our gastrointestinal tract. Targeted effective antibacterial therapies are needed to combat these disease-causing organisms, many of which may be multidrug resistant.

    Sabrina I. Green, Carmen Gu Liu, Xue Yu, Shelley Gibson, Wilhem Salmen, Anubama Rajan, Hannah E. Carter, Justin R. Clark, Xuezheng Song, Robert F. Ramig, Barbara W. Trautner, Heidi B. Kaplan, Anthony W. Maresso
  • Open Access
    The Leader Peptide peTrpL Forms Antibiotic-Containing Ribonucleoprotein Complexes for Posttranscriptional Regulation of Multiresistance Genes
    Research Article | Molecular Biology and Physiology
    The Leader Peptide peTrpL Forms Antibiotic-Containing Ribonucleoprotein Complexes for Posttranscriptional Regulation of Multiresistance Genes

    Leader peptides encoded by transcription attenuators are widespread small proteins that are considered nonfunctional in trans. We found that the leader peptide peTrpL of the soil-dwelling plant symbiont Sinorhizobium meliloti is required for differential, posttranscriptional regulation of a multidrug resistance operon upon antibiotic exposure. Multiresistance...

    Hendrik Melior, Sandra Maaß, Siqi Li, Konrad U. Förstner, Saina Azarderakhsh, Adithi R. Varadarajan, Maximilian Stötzel, Muhammad Elhossary, Susanne Barth-Weber, Christian H. Ahrens, Dörte Becher, Elena Evguenieva-Hackenberg
  • Open Access
    Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance
    Editor's Pick Research Article | Molecular Biology and Physiology
    Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

    Neisseria gonorrhoeae has become a highly antimicrobial-resistant Gram-negative pathogen. Multidrug efflux is a major mechanism that N. gonorrhoeae uses to counteract the action of multiple classes of antibiotics. It appears that gonococci bearing mosaic-like sequences within the gene mtrD...

    Meinan Lyu, Mitchell A. Moseng, Jennifer L. Reimche, Concerta L. Holley, Vijaya Dhulipala, Chih-Chia Su, William M. Shafer, Edward W. Yu
  • Open Access
    Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Research Article | Clinical Science and Epidemiology
    Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae

    In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K. pneumoniae....

    Luchao Lv, Miao Wan, Chengzhen Wang, Xun Gao, Qiwen Yang, Sally R. Partridge, Yang Wang, Zhiyong Zong, Yohei Doi, Jianzhong Shen, Peiyao Jia, Qianhua Song, Qianhui Zhang, Jun Yang, Xianhui Huang, Minggui Wang, Jian-Hua Liu
  • Open Access
    Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells
    Research Article | Therapeutics and Prevention
    Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells

    Novel therapies that avert the problem of Neisseria gonorrhoeae with acquired antibiotic resistance are urgently needed. Gonococcal infection of the human cervix is initiated by an interaction between a galactose modification made to its surface appendages, pili, and the I-domain region of (host) complement receptor 3 (CR3). By targeting this crucial gonococcal–I-...

    Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E.-C. Jen, Victor J. Torres, Jennifer L. Edwards, Michael P. Jennings
  • Open Access
    Comparative Genomics for the Elucidation of Multidrug Resistance in <span class="named-content genus-species" id="named-content-1">Candida lusitaniae</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae

    Antifungal resistance is an inevitable phenomenon when fungal pathogens are exposed to antifungal drugs. These drugs can be grouped in four distinct classes (azoles, candins, polyenes, and pyrimidine analogs) and are used in different clinical settings. Failures in therapy implicate the sequential or combined use of these different drug classes, which can result in some cases in the development of multidrug resistance (MDR). MDR is...

    Abhilash Kannan, Sandra A. Asner, Emilie Trachsel, Steve Kelly, Josie Parker, Dominique Sanglard
  • Open Access
    Multidrug Resistance in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span>: Identification of Functionally Important Residues in the MtrD Efflux Protein
    Research Article | Therapeutics and Prevention
    Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

    With over 78 million new infections globally each year, gonorrhea remains a frustratingly common infection. Continuous development and spread of antimicrobial-resistant strains of Neisseria gonorrhoeae, the causative agent of gonorrhea, have posed a serious threat to public health. One of the mechanisms in...

    Mohsen Chitsaz, Lauren Booth, Mitchell T. Blyth, Megan L. O’Mara, Melissa H. Brown
  • Open Access
    Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in <span class="named-content genus-species" id="named-content-1">Rhodococcus equi</span>
    Research Article | Therapeutics and Prevention
    Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi

    MDR clades arise upon acquisition of resistance traits, but the determinants of their clonal expansion remain largely undefined. Taking advantage of the unique features of Rhodococcus equi infection control in equine farms, involving the same dual antibiotic treatment since the 1980s (a macrolide and rifampin), this study sheds light into the determinants of...

    Sonsiray Álvarez-Narváez, Steeve Giguère, Elisa Anastasi, Jack Hearn, Mariela Scortti, José A. Vázquez-Boland

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