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monocytes

  • Open Access
    Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques
    Research Article | Clinical Science and Epidemiology
    Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

    This study provides further evidence that the latent reservoir is comprised of both CD4+ T cells and myeloid cells. The data presented here suggest that CD4+ T cells and macrophages found throughout tissues in the body can contain replication-competent SIV and contribute to rebound of the virus after treatment interruption. Additionally, we have shown that monocytes in blood contain latent virus and, though not...

    Celina M. Abreu, Rebecca T. Veenhuis, Claudia R. Avalos, Shelby Graham, Daymond R. Parrilla, Edna A. Ferreira, Suzanne E. Queen, Erin N. Shirk, Brandon T. Bullock, Ming Li, Kelly A. Metcalf Pate, Sarah E. Beck, Lisa M. Mangus, Joseph L. Mankowski, Feilim Mac Gabhann, Shelby L. O’Connor, Lucio Gama, Janice E. Clements
  • Open Access
    Barcoded Consortium Infections Resolve Cell Type-Dependent <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Serovar Typhimurium Entry Mechanisms
    Research Article | Host-Microbe Biology
    Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms

    Salmonella enterica serovar Typhimurium (S.Tm) is a widespread and broad-host-spectrum enteropathogen with the capacity to invade diverse cell types. Still, the molecular basis for the host cell invasion process has largely been inferred from studies of a few selected cell lines. Our work resolves the mechanisms that Salmonellae employ to invade...

    Maria Letizia Di Martino, Viktor Ek, Wolf-Dietrich Hardt, Jens Eriksson, Mikael E. Sellin
  • Open Access
    Research Article
    The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformans
    Jorge Masso-Silva, Vanessa Espinosa, Tong-Bao Liu, Yina Wang, Chaoyang Xue, Amariliz Rivera
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