membrane potential
- Editor's Pick Research Article | Ecological and Evolutionary ScienceDe Novo Emergence of Peptides That Confer Antibiotic Resistance
De novo gene origination from nonfunctional DNA sequences was long assumed to be implausible. However, recent studies have shown that large fractions of genomic noncoding DNA are transcribed and translated, potentially generating new genes. Experimental validation of this process so far has been limited to comparative genomics, in vitro selections, or partial randomizations. Here, we describe selection of novel...