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LPS

  • Open Access
    <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin
    Research Article | Host-Microbe Biology
    Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin

    Kaposi’s sarcoma (KS), caused by infection with Kaposi’s sarcoma-associated herpesvirus (KSHV), is one of the most common cancers in AIDS patients. KS is a highly inflammatory tumor, but how KSHV infection induces inflammation remains unclear. We have previously shown that KSHV infection upregulates Toll-like receptor 4 (TLR4), sensitizing cells to lipopolysaccharide (LPS) and...

    Ashley Markazi, Paige M. Bracci, Michael McGrath, Shou-Jiang Gao
  • Open Access
    The O-Antigen Epitope Governs Susceptibility to Colistin in <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span>
    Research Article | Therapeutics and Prevention
    The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica

    Some serovars of Salmonella, namely, those belonging to group D, appear to show a degree of intrinsic resistance to colistin. This observed intrinsic colistin resistance is of concern since this last-resort drug might no longer be effective for treating severe human infections with the most common Salmonella serovar, Salmonella enterica serovar...

    Vito Ricci, Dexian Zhang, Christopher Teale, Laura J. V. Piddock
  • Open Access
    Research Article
    Increased Osmolarity in Biofilm Triggers RcsB-Dependent Lipid A Palmitoylation in Escherichia coli
    Magdalena Szczesny, Christophe Beloin, Jean-Marc Ghigo
  • Open Access
    Observation
    Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes
    Ilia Belotserkovsky, Katja Brunner, Laurie Pinaud, Alexander Rouvinski, Mariano Dellarole, Bruno Baron, Gyanendra Dubey, Fatoumata Samassa, Claude Parsot, Philippe Sansonetti, Armelle Phalipon
  • Open Access
    Editor's Pick Research Article
    Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

    Several pathogenic bacterial species evolved to invade, reside in, and replicate inside the cytosol of their host cells. One adaptation common to most cytosolic bacterial pathogens is the ability to coopt the host’s actin polymerization machinery in order to generate force for intracellular movement. This actin-based motility enables Gram-negative bacteria, such as Shigella species, to propel themselves into neighboring cells,...

    Anthony S. Piro, Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, Jörn Coers
  • Open Access
    Research Article
    Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance

    The LPS from crypt-specific core microbiota controls intestinal epithelium proliferation through necroptosis of stem cells and enhances cell differentiation, mainly the goblet cell lineage.

    Tomoaki Naito, Céline Mulet, Cristina De Castro, Antonio Molinaro, Azadeh Saffarian, Giulia Nigro, Marion Bérard, Mélanie Clerc, Amy B. Pedersen, Philippe J. Sansonetti, Thierry Pédron
  • Open Access
    Research Article
    Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins
    Ryan Finethy, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Meta J. Kuehn, Jörn Coers
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