low-density lipoprotein receptor

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    The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice
    Research Article | Host-Microbe Biology
    The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

    Our results demonstrate a functional role for the commensal microbiota in atherothrombosis. In a ferric chloride injury model of the carotid artery, GF C57BL/6J mice had increased occlusion times compared to colonized controls. Interestingly, in late atherosclerosis, HFD-fed GF Ldlr−/− mice had reduced plaque rupture-induced thrombus growth in the carotid artery and diminished ex vivo thrombus formation...

    Klytaimnistra Kiouptsi, Sven Jäckel, Giulia Pontarollo, Alexandra Grill, Marijke J. E. Kuijpers, Eivor Wilms, Christian Weber, Felix Sommer, Magdolna Nagy, Carlos Neideck, Yvonne Jansen, Stefanie Ascher, Henning Formes, Cornelia Karwot, Franziska Bayer, Bettina Kollar, Saravanan Subramaniam, Michael Molitor, Philip Wenzel, Philip Rosenstiel, Hristo Todorov, Susanne Gerber, Ulrich Walter, Kerstin Jurk, Johan W. M. Heemskerk, Emiel P. C. van der Vorst, Yvonne Döring, Christoph Reinhardt
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