long-read sequencing

  • Open Access
    High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon
    Research Article | Host-Microbe Biology
    High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon

    Achieving strain-level resolution is a major obstacle for source tracking and temporal studies of microbiomes. In this study, we describe a novel deep-sequencing approach that provides species- and strain-level resolution of the neonatal microbiome.

    J. Graf, N. Ledala, M. J. Caimano, E. Jackson, D. Gratalo, D. Fasulo, M. D. Driscoll, S. Coleman, A. P. Matson
  • Open Access
    Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen <span class="named-content genus-species" id="named-content-1">Enterococcus faecium</span>
    Editor's Pick Research Article | Ecological and Evolutionary Science
    Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen Enterococcus faecium

    Enterococcus faecium is one of the most frequent nosocomial pathogens of hospital-acquired infections. E. faecium has gained resistance against most commonly available antibiotics, most notably, against ampicillin, gentamicin, and vancomycin, which renders infections difficult to treat. Many...

    S. Arredondo-Alonso, J. Top, A. McNally, S. Puranen, M. Pesonen, J. Pensar, P. Marttinen, J. C. Braat, M. R. C. Rogers, W. van Schaik, S. Kaski, R. J. L. Willems, J. Corander, A. C. Schürch
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