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Legionella pneumophila

  • Open Access
    Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <em>Legionella</em>
    Minireview | Host-Microbe Biology
    Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella

    Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins that imitate specific eukaryotic cell proteins, allowing them to manipulate host pathways, a phenomenon termed molecular mimicry. Bacterial “eukaryotic-like proteins” are a remarkable example of molecular...

    Sonia Mondino, Silke Schmidt, Carmen Buchrieser
  • Open Access
    Persistent Legionnaires’ Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms
    Research Article | Host-Microbe Biology
    Persistent Legionnaires’ Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms

    The composition and dynamics of the lung microbiome during pneumonia are not known, although the lung microbiome might influence the severity and outcome of this infectious disease, similar to what was shown for the microbiome at other body sites. Here we report the findings of a comprehensive analysis of the lung microbiome composition of three patients with long-term pneumonia due to...

    Ana Elena Pérez-Cobas, Christophe Ginevra, Christophe Rusniok, Sophie Jarraud, Carmen Buchrieser
  • Open Access
    A MicroRNA Network Controls <em>Legionella pneumophila</em> Replication in Human Macrophages via LGALS8 and MX1
    Research Article | Host-Microbe Biology
    A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1

    Cases of Legionella pneumophila pneumonia occur worldwide, with potentially fatal outcome. When causing human disease, Legionella injects a plethora of virulence factors to reprogram macrophages to circumvent immune defense and create a replication niche. By analyzing Legionella-induced changes in miRNA expression and genomewide chromatin...

    Christina E. Herkt, Brian E. Caffrey, Kristin Surmann, Sascha Blankenburg, Manuela Gesell Salazar, Anna L. Jung, Stefanie M. Herbel, Kerstin Hoffmann, Leon N. Schulte, Wei Chen, Alexandra Sittka-Stark, Uwe Völker, Martin Vingron, Annalisa Marsico, Wilhelm Bertrams, Bernd Schmeck
  • Open Access
    Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding
    Research Article | Host-Microbe Biology
    Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding

    Many bacteria use type IV secretion systems (T4SSs) to translocate proteins and nucleic acids into target cells, which promotes DNA transfer and host infection. The Dot/Icm T4SS in Legionella pneumophila is a multiprotein nanomachine that is known to translocate over 300 different protein effectors into eukaryotic host cells. Here, advanced cryoelectron tomography and...

    Donghyun Park, David Chetrit, Bo Hu, Craig R. Roy, Jun Liu
  • Open Access
    IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of <span class="named-content genus-species" id="named-content-1">Legionella pneumophila</span>
    Research Article | Host-Microbe Biology
    IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila

    Legionella pneumophila is one example among many species of pathogenic bacteria that replicate within mammalian macrophages during infection. The immune signaling factor interferon gamma (IFN-γ) blocks L. pneumophila replication in macrophages and is an essential component of the immune response to...

    Jordan V. Price, Daniel Russo, Daisy X. Ji, Roberto A. Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, Russell E. Vance
  • Open Access
    Interaction of the Ankyrin H Core Effector of <em>Legionella</em> with the Host LARP7 Component of the 7SK snRNP Complex
    Research Article | Host-Microbe Biology
    Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex

    For intracellular pathogens to thrive in host cells, an environment that supports survival and replication needs to be established. L. pneumophila accomplishes this through the activity of the ∼330 effector proteins that are injected into host cells during infection. Effector functions range from hijacking host trafficking pathways to altering host cell machinery,...

    Juanita Von Dwingelo, Ivy Yeuk Wah Chung, Christopher T. Price, Lei Li, Snake Jones, Miroslaw Cygler, Yousef Abu Kwaik
  • Open Access
    Research Article
    Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas

    Transmission of L. pneumophila to humans is facilitated by its ability to grow in Acanthamoeba species. We previously documented that type II secretion (T2S) promotes L. pneumophila infection of A. castellanii....

    Richard C. White, Felizza F. Gunderson, Jessica Y. Tyson, Katherine H. Richardson, Theo J. Portlock, James A. Garnett, Nicholas P. Cianciotto
  • Open Access
    Editor's Pick Research Article
    Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment

    Legionella pneumophila has the ability to replicate within human macrophages and amoebal hosts. Here, we report that the host cell cycle influences L. pneumophila intracellular replication. Our data demonstrate that the G1 and G2/M phases of the host cell cycle are permissive for bacterial replication, while S phase is toxic for the bacterium. L. pneumophila replicates poorly within host...

    Dennise A. de Jesús-Díaz, Connor Murphy, Asaf Sol, Marion Dorer, Ralph R. Isberg
  • Open Access
    Research Article
    Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane

    Infection of macrophages and amoebae plays a central role in the pathogenesis of L. pneumophila, the agent of Legionnaires’ disease. We have previously demonstrated that the T2S system of L. pneumophila greatly contributes to intracellular infection. However, the location of T2S substrates within the infected host cell is unknown. This report presents the first evidence of a L. pneumophila T2S substrate in the...

    Hilary K. Truchan, Harry D. Christman, Richard C. White, Nakisha S. Rutledge, Nicholas P. Cianciotto
  • Open Access
    Research Article
    A Unique cis-Encoded Small Noncoding RNA Is Regulating Legionella pneumophila Hfq Expression in a Life Cycle-Dependent Manner

    The abilities of L. pneumophila to replicate intracellularly and to cause disease depend on its capacity to adapt to different extra- and intracellular environmental conditions. Therefore, a timely and fine-tuned expression of virulence factors and adaptation traits is crucial. Yet, the regulatory circuits governing the life cycle of L. pneumophila from replicating to virulent bacteria are only partly uncovered. Here...

    Giulia Oliva, Tobias Sahr, Monica Rolando, Maike Knoth, Carmen Buchrieser
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