LC3

  • Open Access
    ISG15 Connects Autophagy and IFN-γ-Dependent Control of <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> Infection in Human Cells
    Research Article | Host-Microbe Biology
    ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

    Interferon(s) provide the primary defense against intracellular pathogens, a property ascribed to their ability to upregulate interferon-stimulated genes. Due to the sequestered niche occupied by Toxoplasma gondii, the host has elaborated intricate ways to target the parasite within its vacuole. One such mechanism is the recognition by a noncanonical autophagy pathway...

    Jaya Bhushan, Joshua B. Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J. Lenschow, Herbert W. Virgin, L. David Sibley
  • Open Access
    Guanylate Binding Proteins Restrict <span class="named-content genus-species" id="named-content-1">Leishmania donovani</span> Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting
    Research Article | Host-Microbe Biology
    Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting

    The obligate intracellular parasite Leishmania causes the disease leishmaniasis, which is transmitted to mammalian hosts, including humans, via the sandfly vector. Following the bite-induced breach of the skin barrier, Leishmania is known to live and replicate predominantly inside professional phagocytes. Although Leishmania is also able to infect nonphagocytic cells, nonphagocytic cells support limited...

    Arun Kumar Haldar, Utsav Nigam, Masahiro Yamamoto, Jörn Coers, Neena Goyal
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