inhibitors
Research Article | Host-Microbe BiologyDirect Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity LigationEbola virus causes episodic but increasingly frequent outbreaks of severe disease in Middle Africa, as shown by the recently overcome second largest outbreak on record in the Democratic Republic of Congo. Despite considerable effort, FDA-approved antifiloviral therapeutics or targeted interventions are not available yet.
Research Article | Molecular Biology and PhysiologyCryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC TransporterThe wall teichoic acid (WTA) is a major component of cell wall and a pathogenic factor in methicillin-resistant Staphylococcus aureus (MRSA). The ABC transporter TarGH is indispensable for flipping WTA precursor from cytoplasm to the extracellular space, thus making it a promising drug target for anti-MRSA agents. The 3.9-Å cryo-EM structure of a TarGH homolog helps...