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influenza A virus

  • Open Access
    Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection
    Research Article | Host-Microbe Biology
    Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection

    Defective influenza virus particles generated during viral replication carry incomplete viral genomes and can interfere with the replication of competent viruses. These defective genomes are thought to modulate the disease severity and pathogenicity of an influenza virus infection. Different defective viral genomes also introduce another source of variation across a heterogeneous cell population. Evaluating the impact of defective virus...

    Chang Wang, Christian V. Forst, Tsui-wen Chou, Adam Geber, Minghui Wang, Wissam Hamou, Melissa Smith, Robert Sebra, Bin Zhang, Bin Zhou, Elodie Ghedin
  • Open Access
    Research Article
    Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus
    Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
  • Open Access
    Editor's Pick Research Article
    Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools
    Bartram L. Smith, Guifang Chen, Claus O. Wilke, Robert M. Krug
  • Open Access
    Research Article
    A Perfect Storm: Increased Colonization and Failure of Vaccination Leads to Severe Secondary Bacterial Infection in Influenza Virus-Infected Obese Mice
    Erik A. Karlsson, Victoria A. Meliopoulos, Nicholas C. van de Velde, Lee-Ann van de Velde, Beth Mann, Geli Gao, Jason Rosch, Elaine Tuomanen, Jon McCullers, Peter Vogel, Stacey Schultz-Cherry
  • Open Access
    Research Article
    Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy
    Shu-Ming Kuo, Chi-Jene Chen, Shih-Cheng Chang, Tzu-Jou Liu, Yi-Hsiang Chen, Sheng-Yu Huang, Shin-Ru Shih
  • Open Access
    Research Article
    Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs
    Alfred T. Harding, Brook E. Heaton, Rebekah E. Dumm, Nicholas S. Heaton
  • Open Access
    Research Article
    CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

    Influenza virus, particularly influenza A virus, causes severe and frequent outbreaks among human and avian species. Finding potential target sites for antiviral agents is of utmost importance from the public health point of view. We previously found that viral nucleoprotein (NP) is ubiquitinated, and ubiquitination enhances viral RNA replication. In this study, we found a cellular ubiquitin ligase, CNOT4, capable of ubiquitinating NP....

    Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai
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