indole
Author Reply | Host-Microbe BiologyReply to Rockey et al., “Genomics and Chlamydial Persistence In Vivo”
Author Reply | Host-Microbe BiologyReply to Wood and Lee, “Precedence for the Role of Indole with Pathogens”
Letter to the Editor | Applied and Environmental SciencePrecedence for the Role of Indole with Pathogens
Research Article | Host-Microbe BiologyClinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase OperonChlamydia trachomatis (Ct) is the most common sexually transmitted bacterium with more than 131 million cases occurring annually worldwide. Ct infections are often asymptomatic, persisting for many years despite treatment. In vitro recovery from persistence occurs when indole is utilized by the organism’s tryptophan synthase to synthesize...
Research Article | Host-Microbe BiologyIndole Signaling at the Host-Microbiota-Pathogen InterfacePathogens sense and respond to several small molecules within the GI tract to modulate expression of their virulence repertoire. Indole is a signaling molecule produced by the gut microbiota. Here we show that indole concentrations are higher in the lumen, where the microbiota is present, than in the intestinal tissue. The enteric pathogens EHEC and C. rodentium sense...
Research Article | Molecular Biology and PhysiologyIndole Reverses Intrinsic Antibiotic Resistance by Activating a Novel Dual-Function ImporterRecently, signaling molecules were found to play a role in mediating antibiotic resistance. In this study, we demonstrated that indole reversed the intrinsic antibiotic resistance (IRAR) of multiple bacterial species by promoting the expression of a novel dual-function importer. In addition, population-dependent...