Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Latest Articles
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mBio
    • Editor in Chief
    • Board of Editors
    • AAM Fellows
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
mBio
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Latest Articles
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mBio
    • Editor in Chief
    • Board of Editors
    • AAM Fellows
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ

group A streptococcus

  • Open Access
    Intracellular Group A <em>Streptococcus</em> Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase
    Research Article | Host-Microbe Biology
    Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase

    Two prominent virulence factors of group A Streptococcus (GAS), streptolysin O (SLO) and NAD-glycohydrolase (Nga), are linked to enhanced pathogenicity of the prevalent GAS strains. Recent advances show that SLO and Nga are important for intracellular survival of GAS in epithelial cells and macrophages.

    Takashi Nozawa, Junpei Iibushi, Hirotaka Toh, Atsuko Minowa-Nozawa, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
  • Open Access
    Role of Glutathione in Buffering Excess Intracellular Copper in <em>Streptococcus pyogenes</em>
    Research Article | Molecular Biology and Physiology
    Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes

    The control of intracellular metal availability is fundamental to bacterial physiology. In the case of copper (Cu), it has been established that rising intracellular Cu levels eventually fill the metal-sensing site of the endogenous Cu-sensing transcriptional regulator, which in turn induces transcription of a copper export pump. This response caps intracellular Cu availability below a well-defined threshold and prevents Cu toxicity....

    Louisa J. Stewart, Cheryl-lynn Y. Ong, May M. Zhang, Stephan Brouwer, Liam McIntyre, Mark R. Davies, Mark J. Walker, Alastair G. McEwan, Kevin J. Waldron, Karrera Y. Djoko
  • Open Access
    ExPortal and the LiaFSR Regulatory System Coordinate the Response to Cell Membrane Stress in <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span>
    Research Article | Host-Microbe Biology
    ExPortal and the LiaFSR Regulatory System Coordinate the Response to Cell Membrane Stress in Streptococcus pyogenes

    Bacterial two-component systems sense and induce transcriptional changes in response to environmental stressors, including antimicrobials and human antimicrobial peptides. Since the stresses imposed by the host’s defensive responses may act as markers of specific temporal stages of disease progression or host compartments, pathogens often coordinately regulate stress response programs with virulence factor expression. The mechanism by...

    Yibin Lin, Misu A. Sanson, Luis Alberto Vega, Brittany Shah, Shrijana Regmi, M. Belen Cubria, Anthony R. Flores
  • Open Access
    T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span>
    Research Article | Host-Microbe Biology
    T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 Streptococcus pyogenes

    Group A Streptococcus (GAS) is a strict human pathogen causing more than 700 million infections globally each year. The majority of the disease-causing GAS are encapsulated, which greatly guarantees survival and dissemination in the host. Emergence of the capsule-negative GAS, such as M4 GAS, in recent epidemiologic surveillance alarms the necessity to elucidate the virulence determinants of these pathogens. Here, we found that...

    Yi-Hsuan Chen, Shao-Hui Li, Yao-Cheng Yang, Shu-Hao Hsu, Victor Nizet, Yung-Chi Chang
  • Open Access
    The Arginine Deiminase Pathway Impacts Antibiotic Tolerance during Biofilm-Mediated <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span> Infections
    Research Article | Molecular Biology and Physiology
    The Arginine Deiminase Pathway Impacts Antibiotic Tolerance during Biofilm-Mediated Streptococcus pyogenes Infections

    Biofilm-mediated bacterial infections are a major threat to human health because of their recalcitrance to antibiotic treatment. Through the study of Streptococcus pyogenes, a significant human pathogen that is known to form antibiotic-tolerant biofilms, we demonstrated the role that a bacterial pathway known for responding to acid stress plays in biofilm growth and...

    Jeffrey A. Freiberg, Yoann Le Breton, Janette M. Harro, Devon L. Allison, Kevin S. McIver, Mark E. Shirtliff
  • Open Access
    Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A <em>Streptococcus</em> To Initiate Autophagy during Infection
    Research Article | Host-Microbe Biology
    Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus To Initiate Autophagy during Infection

    Autophagy is generally considered a strategy used by the innate immune system to eliminate invasive pathogens through capturing and transferring them to lysosomes. Currently, researchers pay more attention to how virulence factors secreted by GAS regulate the autophagic process. Here, we provide the first evidence that the structural protein FbaA of M1 GAS strain SF370 is a potent inducer of autophagy in epithelial cells. Furthermore,...

    Jiachao Wang, Meiqi Meng, Miao Li, Xiaofei Guan, Jianguo Liu, Xue Gao, Qingqing Sun, Jinquan Li, Cuiqing Ma, Lin Wei
  • Open Access
    Vaccine-Induced Th1-Type Response Protects against Invasive Group A <em>Streptococcus</em> Infection in the Absence of Opsonizing Antibodies
    Research Article | Therapeutics and Prevention
    Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies

    Availability of a group A Streptococcus vaccine remains an unmet public health need. Here, we tested different adjuvant formulations to improve the protective efficacy of non-M protein vaccine Combo5 in an invasive disease model. We show that novel adjuvants can dramatically shape the type of immune response developed following immunization with Combo5 and significantly improve protection. In addition, protection afforded by...

    Tania Rivera-Hernandez, Mira Syahira Rhyme, Amanda J. Cork, Scott Jones, Celia Segui-Perez, Livia Brunner, Johanna Richter, Nikolai Petrovsky, Maria Lawrenz, David Goldblatt, Nicolas Collin, Mark J. Walker
  • Open Access
    The Emergence of Successful <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span> Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression
    Research Article | Ecological and Evolutionary Science
    The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression

    Streptococcus pyogenes is a genetically diverse pathogen, with over 200 different genotypes defined by emm typing, but only a minority of these genotypes are responsible for the majority of human infection in high-income countries. Two prevalent genotypes associated with disease rose to international dominance following recombination of a toxin locus that...

    Claire E. Turner, Matthew T. G. Holden, Beth Blane, Carolyne Horner, Sharon J. Peacock, Shiranee Sriskandan
  • Open Access
    A Multicomponent Vaccine Provides Immunity against Local and Systemic Infections by Group A Streptococcus across Serotypes
    Research Article | Therapeutics and Prevention
    A Multicomponent Vaccine Provides Immunity against Local and Systemic Infections by Group A Streptococcus across Serotypes

    GAS is among the most common human pathogens and causes a wide variety of diseases, likely more than any other microorganism. The diverse clinical manifestations of GAS may be attributable to its large repertoire of virulence factors that are selectively and synergistically involved in streptococcal pathogenesis. To date, GAS vaccines have not been successful due to multiple serotypes and postinfection sequelae associated with...

    Shuai Bi, Meiyi Xu, Ya Zhou, Xinxin Xing, Adong Shen, Beinan Wang
  • Open Access
    A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins
    Research Article | Host-Microbe Biology
    A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins

    M proteins are surface-anchored virulence factors in group A streptococci, human pathogens. Here, we identified an M-like protein, SzM, and its positive regulator, SezV, in Streptococcus equi subspecies zooepidemicus (SEZ), an important group of pathogens for domesticated animals, including horses and pigs. SzM and SezV homologues were found in the genomes of...

    Jonathan D. D’Gama, Zhe Ma, Hailong Zhang, Xu Liu, Hongjie Fan, Ellen Ruth A. Morris, Noah D. Cohen, Colette Cywes-Bentley, Gerald B. Pier, Matthew K. Waldor

Pages

  • Next
  • 1
  • 2
Back to top

About

  • About mBio
  • Editor in Chief
  • Board of Editors
  • AAM Fellows
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Author Warranty
  • Article Types
  • Ethics
  • Contact Us

Follow #mBio

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Online ISSN: 2150-7511