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gene regulation

  • Open Access
    Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> O157:H7
    Research Article | Host-Microbe Biology
    Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7

    Sensing specific gut metabolites is an important strategy for inducing crucial virulence programs by enterohemorrhagic Escherichia coli (EHEC) O157:H7 during colonization and infection. Here, we identified a virulence-regulating pathway wherein the PhoQ/PhoP two-component regulatory system signals to the O island 119-encoded low magnesium-induced regulator A (LmiA),...

    Yutao Liu, Runhua Han, Junyue Wang, Pan Yang, Fang Wang, Bin Yang
  • Open Access
    CsrA-Mediated Translational Activation of <em>ymdA</em> Expression in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    CsrA-Mediated Translational Activation of ymdA Expression in Escherichia coli

    The Csr system of E. coli controls gene expression and physiology on a global scale. CsrA protein, the central component of this system, represses translation initiation of numerous genes by binding to target transcripts, thereby competing with ribosome binding. Variations of this mechanism are so common that CsrA is sometimes called a translational repressor....

    Andrew Renda, Stephanie Poly, Ying-Jung Lai, Archana Pannuri, Helen Yakhnin, Anastasia H. Potts, Philip C. Bevilacqua, Tony Romeo, Paul Babitzke
  • Open Access
    Sigma 54-Regulated Transcription Is Associated with Membrane Reorganization and Type III Secretion Effectors during Conversion to Infectious Forms of <span class="named-content genus-species" id="named-content-1">Chlamydia trachomatis</span>
    Research Article | Molecular Biology and Physiology
    Sigma 54-Regulated Transcription Is Associated with Membrane Reorganization and Type III Secretion Effectors during Conversion to Infectious Forms of Chlamydia trachomatis

    The factors that control the growth and infectious processes for Chlamydia are still poorly understood. This study used recently developed genetic tools to determine the regulon for one of the key transcription factors encoded by Chlamydia, sigma 54. Surrogate and computational analyses provide additional support for the hypothesis that sigma 54 plays a key role in controlling the expression of many components critical...

    Katelyn R. Soules, Scott D. LaBrie, Benjamin H. May, P. Scott Hefty
  • Open Access
    HbtR, a Heterofunctional Homolog of the Virulence Regulator TcpP, Facilitates the Transition between Symbiotic and Planktonic Lifestyles in <span class="named-content genus-species" id="named-content-1">Vibrio fischeri</span>
    Research Article | Host-Microbe Biology
    HbtR, a Heterofunctional Homolog of the Virulence Regulator TcpP, Facilitates the Transition between Symbiotic and Planktonic Lifestyles in Vibrio fischeri

    TcpP homologs are widespread throughout the Vibrio genus; however, the only protein in this family described thus far is a V. cholerae virulence regulator. Here, we show that HbtR, the TcpP homolog in V. fischeri, has both a biological role and regulatory pathway completely unlike those in...

    Brittany D. Bennett, Tara Essock-Burns, Edward G. Ruby
  • Open Access
    The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog <em>ftsZ2</em> To Control Cell Division in Archaea
    Research Article | Molecular Biology and Physiology
    The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea

    Healthy cell growth and division are critical for individual organism survival and species long-term viability. However, it remains unknown how cells of the domain Archaea maintain a healthy cell cycle. Understanding the archaeal cell cycle is of paramount evolutionary importance given that an archaeal cell was the host of the endosymbiotic event that gave rise to eukaryotes. Here, we identify and characterize novel molecular...

    Cynthia L. Darnell, Jenny Zheng, Sean Wilson, Ryan M. Bertoli, Alexandre W. Bisson-Filho, Ethan C. Garner, Amy K. Schmid
  • Open Access
    Temporal Control of the <span class="named-content genus-species" id="named-content-1">Helicobacter pylori</span> Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis
    Research Article | Host-Microbe Biology
    Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

    The “hit-and-run model” of carcinogenesis proposes that an infectious agent triggers carcinogenesis during initial stages of infection and that the ongoing presence of the infectious agent is not required for development of cancer. H. pylori infection and actions of CagA (an effector protein designated a bacterial oncoprotein, secreted by the Cag T4SS) are proposed to...

    Aung Soe Lin, Mark S. McClain, Amber C. Beckett, Rhonda R. Caston, M. Lorena Harvey, Beverly R. E. A. Dixon, Anne M. Campbell, Jennifer H. B. Shuman, Neha Sawhney, Alberto G. Delgado, John T. Loh, M. Blanca Piazuelo, Holly M. Scott Algood, Timothy L. Cover
  • Open Access
    Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites
    Research Article | Host-Microbe Biology
    Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites

    Malaria remains a major public health and economic burden. The heterochromatin environment controls the silencing of genes associated with the fate of malaria parasites. Previous studies have demonstrated that a group of GC-rich ncRNAs (RUF6) is associated with the mutually exclusive expression of var genes, but the underlying mechanisms remain elusive. Here, through a series of genetic manipulation and genome-wide multiomics...

    Yanting Fan, Shijun Shen, Guiying Wei, Jianxia Tang, Yuemeng Zhao, Fei Wang, Xiaohui He, Gangqiang Guo, Xiaomin Shang, Xinyu Yu, Zhenlin Ma, Xiaoqin He, Meng Liu, Qianshu Zhu, Zhen Le, Gang Wei, Jun Cao, Cizhong Jiang, Qingfeng Zhang
  • Open Access
    Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans

    Candida albicans is a major human fungal pathogen and the leading cause of systemic Candida infections. In recent years, Als3 and Ece1 were identified as important factors for fungal virulence. Transcription of both corresponding genes is closely associated with hyphal growth. Here, we describe how Tup1, normally a global repressor of gene expression as well...

    Sophia Ruben, Enrico Garbe, Selene Mogavero, Daniela Albrecht-Eckardt, Daniela Hellwig, Antje Häder, Thomas Krüger, Katrin Gerth, Ilse D. Jacobsen, Osama Elshafee, Sascha Brunke, Kerstin Hünniger, Olaf Kniemeyer, Axel A. Brakhage, Joachim Morschhäuser, Bernhard Hube, Slavena Vylkova, Oliver Kurzai, Ronny Martin
  • Open Access
    RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria
    Research Article | Molecular Biology and Physiology
    RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria

    G-quadruplex in RNA (rG4) mediates various biological functions and cellular processes in eukaryotic organisms. However, the presence, locations, and functions of rG4 are still elusive in prokaryotes. Here, we found that rG4 is an abundant RNA secondary structure across a wide range of bacterial species. Subsequently, the transcriptome-wide rG4 structure sequencing (rG4-seq) revealed that the model...

    Xiaolong Shao, Weitong Zhang, Mubarak Ishaq Umar, Hei Yuen Wong, Zijing Seng, Yingpeng Xie, Yingchao Zhang, Liang Yang, Chun Kit Kwok, Xin Deng
  • Open Access
    Stochastic Expression of Sae-Dependent Virulence Genes during <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Biofilm Development Is Dependent on SaeS
    Research Article | Molecular Biology and Physiology
    Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS

    Staphylococcus aureus is an important human pathogen capable of colonizing diverse tissue types and inducing severe disease in both immunocompromised and otherwise healthy individuals. Biofilm infections caused by this bacterial species are of particular concern because of their persistence, even in the face of intensive therapeutic intervention. The results of the...

    Elizabeth A. DelMain, Derek E. Moormeier, Jennifer L. Endres, Rebecca E. Hodges, Marat R. Sadykov, Alexander R. Horswill, Kenneth W. Bayles

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