GATA4

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    Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway
    Research Article | Molecular Biology and Physiology
    Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway

    High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate the ATR DNA damage repair pathway, and this is required for HPV genome amplification. In the present study, we show that HPV-induced ATR activation also leads to suppression of expression of inflammatory response genes. This suppression results from HPV-induced phosphorylation of the...

    Shiyuan Hong, Yan Li, Paul J. Kaminski, Jorge Andrade, Laimonis A. Laimins
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