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ESCRT

  • Open Access
    Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration
    Research Article | Molecular Biology and Physiology
    Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration

    LMP1 is a notable viral protein that contributes to the modification of EV content and tumor microenvironment remodeling. LMP1-modified EVs enhance tumor proliferation, migration, and invasion potential and promote radioresistance. Currently, the mechanisms surrounding LMP1 incorporation into the host EV pathways are not well understood. This study revealed that LMP1 utilizes Hrs, Syntenin-1, and specific components of the ESCRT-III...

    Dingani Nkosi, Li Sun, Leanne C. Duke, Nilkumar Patel, Sunil K. Surapaneni, Mandip Singh, David G. Meckes
  • Open Access
    Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea
    Research Article | Ecological and Evolutionary Science
    Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea

    The discovery of Asgard archaea has changed the existing ideas on the origins of eukaryotes. Researchers propose that eukaryotic cells evolved from Asgard archaea. This hypothesis partly stems from the presence of multiple eukaryotic signature proteins in Asgard archaea, including homologs of ESCRT proteins that are essential components of the endomembrane system in eukaryotes. However, structural and functional features of Asgard ESCRT...

    Zhongyi Lu, Ting Fu, Tianyi Li, Yang Liu, Siyu Zhang, Jinquan Li, Junbiao Dai, Eugene V. Koonin, Guohui Li, Huiying Chu, Meng Li
  • Open Access
    The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection
    Research Article | Host-Microbe Biology
    The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection

    Neurons rely on IFNs and autophagy as major defenses against viral infections, and HSV must overcome such defenses in order to replicate. In addition to controlling host immunity, HSV must also control host membranes in order to complete its life cycle. HSV uses the host ESCRT membrane scission machinery for viral production and transport. Here we present evidence of a new IFN-dependent mechanism used by the host to prevent ESCRT...

    Jorge Ruben Cabrera, Richard Manivanh, Brian J. North, David A. Leib
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response
    Research Article | Host-Microbe Biology
    Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

    Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms. Like many intracellular pathogens, in order to cause disease,...

    Ekansh Mittal, Michael L. Skowyra, Grace Uwase, Emir Tinaztepe, Alka Mehra, Stefan Köster, Phyllis I. Hanson, Jennifer A. Philips
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