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EF-Tu

  • Open Access
    Research Article | Molecular Biology and Physiology
    Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

    A feature of bacterial chromosomes is that highly expressed essential genes are usually located close to the origin of replication. Because bacteria have overlapping cycles of replication, genes located close to the origin will often be present in multiple copies, and this is thought to be of selective benefit where high levels of expression support high growth rate. However, the magnitude of this selective effect and whether other...

    Eva Garmendia, Gerrit Brandis, Diarmaid Hughes
  • Open Access
    Research Article
    Simultaneous Binding of Multiple EF-Tu Copies to Translating Ribosomes in Live Escherichia coli
    Mainak Mustafi, James C. Weisshaar
  • Open Access
    Research Article
    Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

    Horizontal gene transfer (HGT) is a fundamental driving force in bacterial evolution. However, whether essential genes can be acquired by HGT and whether they can be acquired from distant organisms are very poorly understood. By systematically replacing tuf with ancestral homologs and homologs from distantly related organisms, we investigated the constraints on HGT of a highly conserved gene with multiple interaction partners....

    Betül Kacar, Eva Garmendia, Nurcan Tuncbag, Dan I. Andersson, Diarmaid Hughes
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