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EBV

  • Open Access
    Kaposi’s Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma
    Research Article | Host-Microbe Biology
    Kaposi’s Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma

    Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the aggressive disease primary effusion lymphoma (PEL). Here, we show that a viral transcription factor (vIRF3) cooperates with the cellular transcription factor IRF4 to control an oncogenic gene expression program in PEL cells. These proteins promote KSHV-mediated B cell transformation by activating the expression of prosurvival genes through super-enhancers. Our report thus...

    Mark Manzano, Thomas Günther, Hyunwoo Ju, John Nicholas, Elizabeth T. Bartom, Adam Grundhoff, Eva Gottwein
  • Open Access
    Epstein-Barr Virus Epitope–Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires
    Research Article | Host-Microbe Biology
    Epstein-Barr Virus Epitope–Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires

    Several lines of evidence suggest that TCRα and TCRβ repertoires play a role in disease outcomes and treatment strategies during viral infections in transplant patients and in cancer and autoimmune disease therapy. Our data suggest that it is essential that we understand the basic principles of how to drive optimum repertoires for both TCR chains, α and β. We address this important issue by characterizing the CD8 TCR repertoire to a...

    Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio Clark, Dario Ghersi, Katherine Luzuriaga, Liisa K. Selin
  • Open Access
    Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle
    Research Article | Host-Microbe Biology
    Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle

    Latent infection by Epstein-Barr virus (EBV) is an early event in the development of EBV-associated carcinomas. In oral epithelial tissues, EBV establishes a lytic infection of differentiated epithelial cells to facilitate the spread of the virus to new hosts. Because of limitations in existing model systems, the effects of latent EBV infection on undifferentiated and differentiating epithelial cells are poorly understood. Here, we...

    Mark R. Eichelberg, Rene Welch, J. Tod Guidry, Ahmed Ali, Makoto Ohashi, Kathleen R. Makielski, Kyle McChesney, Nicholas Van Sciver, Paul F. Lambert, Sündüz Keleș, Shannon C. Kenney, Rona S. Scott, Eric Johannsen
  • Open Access
    Gammaherpesvirus RNAs Come Full Circle
    Minireview | Host-Microbe Biology
    Gammaherpesvirus RNAs Come Full Circle

    After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs) and microRNAs have been recognized for some time and have been actively investigated, a recent spate of reports have now identified repertoires of the circular RNA (...

    Nathan A. Ungerleider, Scott A. Tibbetts, Rolf Renne, Erik K. Flemington
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