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drug resistance evolution

  • Open Access
    Evolution of Fluconazole-Resistant <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Strains by Drug-Induced Mating Competence and Parasexual Recombination
    Research Article | Molecular Biology and Physiology
    Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination

    Sexual reproduction is an important mechanism in the evolution of species, since it allows the combination of advantageous traits of individual members in a population. The pathogenic yeast Candida albicans is a diploid organism that normally propagates in a clonal fashion, because heterozygosity at the mating type locus (MTL) inhibits mating between cells....

    Christina Popp, Bernardo Ramírez-Zavala, Sonja Schwanfelder, Ines Krüger, Joachim Morschhäuser
  • Open Access
    Letter to the Editor
    How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir
    Atze T. Das, Ben Berkhout
  • Open Access
    Research Article
    The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance

    A comprehensive analysis of all intact mcr-1 sequences in GenBank was used to identify a region on the chromosome of a novel Moraxella species with remarkable homology to the canonical mcr-1 structure and that likely represents the origin of this important gene. These data also demonstrate that all mcr-1 structures lacking one or both flanking ISApl1 were formed from ancestral composite...

    Erik Snesrud, Patrick McGann, Michael Chandler
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