DNA, Ancient

  • Open Access
    Research Article
    Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

    Horizontal gene transfer (HGT) is a fundamental driving force in bacterial evolution. However, whether essential genes can be acquired by HGT and whether they can be acquired from distant organisms are very poorly understood. By systematically replacing tuf with ancestral homologs and homologs from distantly related organisms, we investigated the constraints on HGT of a highly conserved gene with multiple interaction partners....

    Betül Kacar, Eva Garmendia, Nurcan Tuncbag, Dan I. Andersson, Diarmaid Hughes
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