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cyclic di-GMP

  • Open Access
    <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection
    Editor's Pick Research Article | Ecological and Evolutionary Science
    Pseudomonas aeruginosa Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection

    Bacteria adapt to infections by evolving variants that are more fit and persistent. These recalcitrant variants are typically observed in chronic infections. However, it is unclear when and why these variants evolve. To address these questions, we used a porcine chronic wound model to study the evolutionary dynamics of Pseudomonas aeruginosa in a mixed-strain...

    Erin S. Gloag, Christopher W. Marshall, Daniel Snyder, Gina R. Lewin, Jacob S. Harris, Alfonso Santos-Lopez, Sarah B. Chaney, Marvin Whiteley, Vaughn S. Cooper, Daniel J. Wozniak
  • Open Access
    DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in <em>Escherichia coli</em> ECOR31
    Research Article | Molecular Biology and Physiology
    DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31

    The ability of bacteria to sense and respond to environmental signals is critical for survival. Bacteria use cyclic dinucleotides as second messengers to regulate a number of physiological processes, such as the fundamental life style transition between motility and sessility (biofilm formation). cGAMP, which is synthesized by a dinucleotide cyclase called DncV, is a newly discovered second messenger involved in virulence and chemotaxis...

    Fengyang Li, Annika Cimdins, Manfred Rohde, Lothar Jänsch, Volkhard Kaever, Manfred Nimtz, Ute Römling
  • Open Access
    Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of <em>Pseudomonas aeruginosa</em> during Dual-Species Biofilm Development with <em>Staphylococcus aureus</em>
    Research Article | Molecular Biology and Physiology
    Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus

    Bacteria in natural and engineered environments form biofilms that include many different species. Microorganisms rely on a number of different strategies to manage social interactions with other species and to access resources, build biofilm consortia, and optimize growth. For example, Pseudomonas...

    Su Chuen Chew, Joey Kuok Hoong Yam, Artur Matysik, Zi Jing Seng, Janosch Klebensberger, Michael Givskov, Patrick Doyle, Scott A. Rice, Liang Yang, Staffan Kjelleberg
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