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CsrA

  • Open Access
    CsrA-Mediated Translational Activation of <em>ymdA</em> Expression in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    CsrA-Mediated Translational Activation of ymdA Expression in Escherichia coli

    The Csr system of E. coli controls gene expression and physiology on a global scale. CsrA protein, the central component of this system, represses translation initiation of numerous genes by binding to target transcripts, thereby competing with ribosome binding. Variations of this mechanism are so common that CsrA is sometimes called a translational repressor....

    Andrew Renda, Stephanie Poly, Ying-Jung Lai, Archana Pannuri, Helen Yakhnin, Anastasia H. Potts, Philip C. Bevilacqua, Tony Romeo, Paul Babitzke
  • Open Access
    Control of Type III Secretion System Effector/Chaperone Ratio Fosters Pathogen Adaptation to Host-Adherent Lifestyle
    Research Article | Host-Microbe Biology
    Control of Type III Secretion System Effector/Chaperone Ratio Fosters Pathogen Adaptation to Host-Adherent Lifestyle

    Host colonization by extracellular pathogens often entails the transition from a planktonic lifestyle to a host-attached state. Enteropathogenic E. coli (EPEC), a Gram-negative pathogen, attaches to the intestinal epithelium of the host and employs a type III secretion system (T3SS) to inject effector proteins into the cytoplasm of infected cells. The most abundant...

    Netanel Elbaz, Yaakov Socol, Naama Katsowich, Ilan Rosenshine
  • Open Access
    Regulation of Iron Storage by CsrA Supports Exponential Growth of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article | Molecular Biology and Physiology
    Regulation of Iron Storage by CsrA Supports Exponential Growth of Escherichia coli

    Iron is an essential micronutrient for nearly all living organisms but is toxic in excess. Consequently, the maintenance of iron homeostasis is a critical biological process, and the genes involved in this function are tightly regulated. Here, we explored a new role for the bacterial RNA binding protein CsrA in the regulation of iron homeostasis. CsrA was shown to be a key regulator of iron storage genes in...

    Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span> CsrA Directly Regulates <em>varA</em> To Increase Expression of the Three Nonredundant Csr Small RNAs
    Research Article | Molecular Biology and Physiology
    Vibrio cholerae CsrA Directly Regulates varA To Increase Expression of the Three Nonredundant Csr Small RNAs

    Vibrio cholerae is a major human pathogen, causing epidemics and pandemics of cholera. V. cholerae persists in the aquatic environment, providing a constant source for human infection. Success in transitioning from the environment to the human host and back requires the bacterium to rapidly respond...

    Heidi A. Butz, Alexandra R. Mey, Ashley L. Ciosek, Shelley M. Payne
  • Open Access
    Research Article
    Translational Repression of the RpoS Antiadapter IraD by CsrA Is Mediated via Translational Coupling to a Short Upstream Open Reading Frame

    CsrA posttranscriptionally represses gene expression associated with stationary-phase bacterial growth, often in opposition to the transcriptional effects of the stationary-phase sigma factor RpoS. We show that CsrA employs a novel regulatory mechanism to repress translation of iraD, which encodes an antiadapter protein that protects RpoS against proteolysis. CsrA binds to four sites in the iraD leader transcript but...

    Hongmarn Park, Louise C. McGibbon, Anastasia H. Potts, Helen Yakhnin, Tony Romeo, Paul Babitzke
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