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cryptococcosis

  • Open Access
    The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span>
    Research Article | Host-Microbe Biology
    The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans

    Cryptococcus neoformans is the causative agent of cryptococcal meningitis, a disease responsible for ∼15% of all HIV-related deaths. Unfortunately, development of antifungal drugs is challenging because potential targets are conserved between humans and C. neoformans. In this context, we...

    Linda C. Horianopoulos, Guanggan Hu, Mélissa Caza, Kerstin Schmitt, Peter Overby, James D. Johnson, Oliver Valerius, Gerhard H. Braus, James W. Kronstad
  • Open Access
    CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis
    Research Article | Host-Microbe Biology
    CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis

    Cryptococcus neoformans is a fungal pathogen that is found throughout the environment and can cause life-threatening infections of the lung and central nervous system in severely immunocompromised individuals. Caspase recruitment domain-containing protein 9 (CARD9) is a critical molecule that is activated after interactions of C-type lectin receptors (CLRs) found on...

    Althea Campuzano, Natalia Castro-Lopez, Amanda J. Martinez, Michal A. Olszewski, Anutosh Ganguly, Chrissy Leopold Wager, Chiung-Yu Hung, Floyd L. Wormley
  • Open Access
    Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span> Infection
    Research Article | Host-Microbe Biology
    Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection

    Even with the best available care, mortality rates in cryptococcal meningitis range from 20% to 60%. Disease is often due to infection by the fungus Cryptococcus neoformans and involves a complex interaction between the human host and the fungal pathogen. Although previous studies have suggested genetic differences in the pathogen impact human disease, it has proven...

    Aleeza C. Gerstein, Katrina M. Jackson, Tami R. McDonald, Yina Wang, Benjamin D. Lueck, Sara Bohjanen, Kyle D. Smith, Andrew Akampurira, David B. Meya, Chaoyang Xue, David R. Boulware, Kirsten Nielsen
  • Open Access
    The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span>
    Research Article | Host-Microbe Biology
    The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans

    Fungal pathogens cause life-threatening diseases in humans, particularly in immunocompromised people, and there is a tremendous need for a greater understanding of pathogenesis to support new therapies. One prominent fungal pathogen, Cryptococcus neoformans, causes meningitis in people suffering from HIV/AIDS. In the present study, we focused on characterizing...

    Rodgoun Attarian, Guanggan Hu, Eddy Sánchez-León, Mélissa Caza, Daniel Croll, Eunsoo Do, Horacio Bach, Tricia Missall, Jennifer Lodge, Won Hee Jung, James W. Kronstad
  • Open Access
    Commentary
    Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response
    Liise-anne Pirofski, Arturo Casadevall
  • Open Access
    Research Article
    Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

    The encapsulated fungi Cryptococcus neoformans and Cryptococcus gattii are responsible for nearly 200,000 deaths annually, mostly in immunocompromised individuals. An effective vaccine could substantially reduce the burden of cryptococcosis. However, a major gap in cryptococcal vaccine development has been the discovery of protective antigens to use in vaccines. Here, six cryptococcal proteins with potential as vaccine...

    Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz
  • Open Access
    Research Article
    CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis
    Lori M. Neal, Enze Xing, Jintao Xu, Jessica L. Kolbe, John J. Osterholzer, Benjamin M. Segal, Peter R. Williamson, Michal A. Olszewski
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